CTR9

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CTR9
Identifiers
Aliases CTR9, SH2BP1, TSBP, p150, p150TSP, CTR9 homolog, Paf1/RNA polymerase II complex component
External IDs MGI: 109345 HomoloGene: 40668 GeneCards: CTR9
Gene location (Human)
Chromosome 11 (human)
Chr. Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for CTR9
Genomic location for CTR9
Band 11p15.4 Start 10,750,987 bp[1]
End 10,801,625 bp[1]
RNA expression pattern
PBB GE CTR9 202060 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014633
NM_001346279

NM_009431

RefSeq (protein)

NP_001333208
NP_055448

NP_033457

Location (UCSC) Chr 11: 10.75 – 10.8 Mb Chr 7: 111.03 – 111.06 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

RNA polymerase-associated protein CTR9 homolog is an enzyme that in humans is encoded by the CTR9 gene.[5][6][7]


Model organisms[edit]

Model organisms have been used in the study of CTR9 function. A conditional knockout mouse line called Ctr9tm1b(EUCOMM)Wtsi was generated at the Wellcome Trust Sanger Institute.[8] Male and female animals underwent a standardized phenotypic screen[9] to determine the effects of deletion.[10][11][12][13] Additional screens performed: - In-depth immunological phenotyping[14]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000198730 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000005609 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N (Mar 1996). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (4): 167–74, 199–210. doi:10.1093/dnares/2.4.167. PMID 8590280. 
  6. ^ Malek SN, Yang CH, Earnshaw WC, Kozak CA, Desiderio S (Jul 1996). "p150TSP, a conserved nuclear phosphoprotein that contains multiple tetratricopeptide repeats and binds specifically to SH2 domains". J Biol Chem. 271 (12): 6952–62. doi:10.1074/jbc.271.12.6952. PMID 8636124. 
  7. ^ "Entrez Gene: CTR9 Ctr9, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)". 
  8. ^ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. 
  9. ^ a b "International Mouse Phenotyping Consortium". 
  10. ^ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410Freely accessible. PMID 21677750. 
  11. ^ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718. 
  12. ^ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. 
  13. ^ White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Sanger Institute Mouse Genetics Project, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell. 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMC 3717207Freely accessible. PMID 23870131. 
  14. ^ a b "Infection and Immunity Immunophenotyping (3i) Consortium". 

External links[edit]

Further reading[edit]