Cathepsin O

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CTSO
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CTSO, CTSO1, cathepsin O
External IDs OMIM: 600550 MGI: 2139628 HomoloGene: 1020 GeneCards: CTSO
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001334

NM_177662

RefSeq (protein)

NP_001325

NP_808330.1
NP_808330

Location (UCSC) Chr 4: 155.92 – 155.95 Mb Chr 3: 81.93 – 81.96 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Cathepsin O is an enzyme that in humans is encoded by the CTSO gene.[3][4]

Function[edit]

Cathepsin O is a cysteine protease and a member of the cathepsin family and papain superfamily. This proteolytic enzyme is involved in cellular protein degradation and turnover. The recombinant form of this enzyme was shown to degrade synthetic peptides typically used as substrates for cysteine proteinases and its proteolytic activity was abolished by an inhibitor of cyteine proteinase.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Santamaría I, Pendás AM, Velasco G, López-Otín C (October 1998). "Genomic structure and chromosomal localization of the human cathepsin O gene (CTSO)". Genomics. 53 (2): 231–4. doi:10.1006/geno.1997.5180. PMID 9790772. 
  4. ^ a b "Entrez Gene: cathepsin O". 

Further reading[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: C01.035

This article incorporates text from the United States National Library of Medicine, which is in the public domain.