Cathepsin O

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CTSO
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCTSO, CTSO1, cathepsin O
External IDsOMIM: 600550 MGI: 2139628 HomoloGene: 1020 GeneCards: CTSO
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for CTSO
Genomic location for CTSO
Band4q32.1Start155,924,118 bp[1]
End155,953,917 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001334

NM_177662

RefSeq (protein)

NP_001325

NP_808330

Location (UCSC)Chr 4: 155.92 – 155.95 MbChr 3: 81.93 – 81.96 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cathepsin O is an enzyme that in humans is encoded by the CTSO gene.[5][6]

Function[edit]

Cathepsin O is a cysteine protease and a member of the cathepsin family and papain superfamily. This proteolytic enzyme is involved in cellular protein degradation and turnover. The recombinant form of this enzyme was shown to degrade synthetic peptides typically used as substrates for cysteine proteinases and its proteolytic activity was abolished by an inhibitor of cyteine proteinase.[6]

References[edit]

  1. ^ a b c ENSG00000256043 GRCh38: Ensembl release 89: ENSG00000263238, ENSG00000256043 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028015 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Santamaría I, Pendás AM, Velasco G, López-Otín C (October 1998). "Genomic structure and chromosomal localization of the human cathepsin O gene (CTSO)". Genomics. 53 (2): 231–4. doi:10.1006/geno.1997.5180. PMID 9790772.
  6. ^ a b "Entrez Gene: cathepsin O".

Further reading[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: C01.035

This article incorporates text from the United States National Library of Medicine, which is in the public domain.