From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
Protein CUL5 PDB 3DPL.png
Available structures
PDBOrtholog search: PDBe RCSB
AliasesCUL5, VACM-1, VACM1, cullin 5, CUL-5
External IDsOMIM: 601741 MGI: 1922967 HomoloGene: 2597 GeneCards: CUL5
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 11: 108.01 – 108.11 MbChr 9: 53.61 – 53.67 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Cullin-5 is a protein that in humans is encoded by the CUL5 gene.[5][6][7]


The mammalian gene product was originally discovered by expression cloning, due to the protein's ability to mobilize intracellular calcium in response to the peptide hormone arginine vasopressin. It was first titled VACM-1, for vasopressin-activated, calcium-mobilizing receptor.[8] Since then, VACM-1 has been shown to be homologous to the Cullin family of proteins, and was subsequently dubbed cul5.

Tissue distribution[edit]

Studies have shown that the cul5 protein is expressed at its highest levels in heart and skeletal tissue, and is specifically expressed in vascular endothelium and renal collecting tubules.[9]


Cul5 inhibits cellular proliferation, potentially through its involvement in the SOCS/ BC-box/ eloBC/ cul5/ RING E3 ligase complex, which functions as part of the ubiquitin system for protein degradation.[10]

One study have shown that Cul5 plays a role in Reelin signaling cascade, participating in the DAB1 degradation and thus ensuring the negative feedback mechanism of Reelin signaling during corticogenesis.[11]


CUL5 has been shown to interact with RBX1.[12][13]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000166266 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032030 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kipreos ET, Lander LE, Wing JP, He WW, Hedgecock EM (Aug 1996). "cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family". Cell. 85 (6): 829–39. doi:10.1016/S0092-8674(00)81267-2. PMID 8681378. S2CID 15805562.
  6. ^ Byrd PJ, Stankovic T, McConville CM, Smith AD, Cooper PR, Taylor AM (May 1997). "Identification and analysis of expression of human VACM-1, a cullin gene family member located on chromosome 11q22-23". Genome Res. 7 (1): 71–5. doi:10.1101/gr.7.1.71. PMID 9037604.
  7. ^ "Entrez Gene: CUL5 cullin 5".
  8. ^ Burnatowska-Hledin MA, Spielman WS, Smith WL, et al. (1995). "Expression cloning of an AVP-activated, calcium-mobilizing receptor from rabbit kidney medulla". Am J Physiol. 268 (6): F1198–210. doi:10.1152/ajprenal.1995.268.6.F1198. PMID 7611460.
  9. ^ Burnatowska-Hledin M, Lazdins IB, Listenberger L, et al. (1999). "VACM-1 receptor is specifically expressed in rabbit vascular endothelium and renal collecting tubule". Am J Physiol. 276 (2 Pt 2): F199–209. doi:10.1152/ajprenal.1999.276.2.F199. PMID 9950950.
  10. ^ Petroski MD, Deshaies RJ (2005). "Function and regulation of cullin-RING E3 ligases" (PDF). Nature Reviews Molecular Cell Biology. 6 (1): 9–21. doi:10.1038/nrm1547. PMID 15688063. S2CID 24159190.
  11. ^ Feng L, Allen NS, Simo S, Cooper JA (November 2007). "Cullin 5 regulates Dab1 protein levels and neuron positioning during cortical development". Genes Dev. 21 (21): 2717–30. doi:10.1101/gad.1604207. PMC 2045127. PMID 17974915.
  12. ^ Duda, David M; Borg Laura A; Scott Daniel C; Hunt Harold W; Hammel Michal; Schulman Brenda A (Sep 2008). "Structural Insights into NEDD8 Activation of Cullin-RING Ligases: Conformational Control of Conjugation". Cell. United States. 134 (6): 995–1006. doi:10.1016/j.cell.2008.07.022. PMC 2628631. PMID 18805092.
  13. ^ Ohta, T; Michel J J; Schottelius A J; Xiong Y (Apr 1999). "ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity". Mol. Cell. UNITED STATES. 3 (4): 535–41. doi:10.1016/S1097-2765(00)80482-7. ISSN 1097-2765. PMID 10230407.

External links[edit]

Further reading[edit]