CUL7

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CUL7
Protein CUL7 PDB 2jng.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCUL7, 3M1, KIAA0076, dJ20C7.5, cullin 7, CUL-7
External IDsMGI: 1913765 HomoloGene: 56683 GeneCards: CUL7
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for CUL7
Genomic location for CUL7
Band6p21.1Start43,037,617 bp[1]
End43,053,945 bp[1]
RNA expression pattern
PBB GE CUL7 36084 at fs.png

PBB GE CUL7 203558 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001168370
NM_014780

NM_025611

RefSeq (protein)

NP_001161842
NP_055595

NP_079887

Location (UCSC)Chr 6: 43.04 – 43.05 MbChr 17: 46.65 – 46.66 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cullin-7 is a RING-E3 ligase protein that in humans is encoded by the CUL7 gene.[5][6][7]

Clinical significance[edit]

It is associated with 3-M syndrome.

Interactions[edit]

CUL7 has been shown to interact with RBX1.[5]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000044090 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038545 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ a b Dias DC, Dolios G, Wang R, Pan ZQ (Dec 2002). "CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex". Proc Natl Acad Sci U S A. 99 (26): 16601–6. doi:10.1073/pnas.252646399. PMC 139190. PMID 12481031.
  6. ^ Arai T, Kasper JS, Skaar JR, Ali SH, Takahashi C, DeCaprio JA (Aug 2003). "Targeted disruption of p185/Cul7 gene results in abnormal vascular morphogenesis". Proc Natl Acad Sci U S A. 100 (17): 9855–60. doi:10.1073/pnas.1733908100. PMC 187864. PMID 12904573.
  7. ^ "Entrez Gene: CUL7 cullin 7".

Further reading[edit]

External links[edit]