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Cullin 7
Protein CUL7 PDB 2jng.png
PDB rendering based on 2jng.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CUL7 ; 3M1; KIAA0076; dJ20C7.5
External IDs OMIM609577 MGI1913765 HomoloGene56683 GeneCards: CUL7 Gene
RNA expression pattern
PBB GE CUL7 203558 at tn.png
PBB GE CUL7 36084 at tn.png
More reference expression data
Species Human Mouse
Entrez 9820 66515
Ensembl ENSG00000044090 ENSMUSG00000038545
UniProt Q14999 Q8VE73
RefSeq (mRNA) NM_001168370 NM_025611
RefSeq (protein) NP_001161842 NP_079887
Location (UCSC) Chr 6:
43.04 – 43.05 Mb
Chr 17:
46.65 – 46.66 Mb
PubMed search [1] [2]

Cullin-7 is a RING-E3 ligase protein that in humans is encoded by the CUL7 gene.[1][2][3]

Clinical significance[edit]

It is associated with 3-M syndrome.


CUL7 has been shown to interact with RBX1.[1]


  1. ^ a b Dias DC, Dolios G, Wang R, Pan ZQ (Dec 2002). "CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex". Proc Natl Acad Sci U S A 99 (26): 16601–6. doi:10.1073/pnas.252646399. PMC 139190. PMID 12481031. 
  2. ^ Arai T, Kasper JS, Skaar JR, Ali SH, Takahashi C, DeCaprio JA (Aug 2003). "Targeted disruption of p185/Cul7 gene results in abnormal vascular morphogenesis". Proc Natl Acad Sci U S A 100 (17): 9855–60. doi:10.1073/pnas.1733908100. PMC 187864. PMID 12904573. 
  3. ^ "Entrez Gene: CUL7 cullin 7". 

Further reading[edit]

External links[edit]