CXCL11

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CXCL11
Protein CXCL11 PDB 1rjt.png
Available structures
PDB Human UniProt search: PDBe RCSB
Identifiers
Aliases CXCL11, H174, I-TAC, IP-9, IP9, SCYB11, SCYB9B, b-R1, C-X-C motif chemokine ligand 11
External IDs OMIM: 604852 HomoloGene: 3944 GeneCards: 6373
RNA expression pattern
PBB GE CXCL11 210163 at tn.png

PBB GE CXCL11 211122 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005409
NM_001302123

n/a

RefSeq (protein)

NP_001289052.1
NP_005400.1

n/a

Location (UCSC) Chr 4: 76.03 – 76.04 Mb n/a
PubMed search [1] n/a
Wikidata
View/Edit Human

C-X-C motif chemokine 11 (CXCL11) is a protein that in humans is encoded by the CXCL11 gene.[1]

C-X-C motif chemokine 11 is a small cytokine belonging to the CXC chemokine family that is also called Interferon-inducible T-cell alpha chemoattractant (I-TAC) and Interferon-gamma-inducible protein 9 (IP-9). It is highly expressed in peripheral blood leukocytes, pancreas and liver, with moderate levels in thymus, spleen and lung and low expression levels were in small intestine, placenta and prostate.[2]

Gene expression of CXCL11 is strongly induced by IFN-γ and IFN-β, and weakly induced by IFN-α.[3] This chemokine elicits its effects on its target cells by interacting with the cell surface chemokine receptor CXCR3, with a higher affinity than do the other ligands for this receptor, CXCL9 and CXCL10.[2][4] CXCL11 is chemotactic for activated T cells. Its gene is located on human chromosome 4 along with many other members of the CXC chemokine family.[5][6]

References[edit]

  1. ^ "Entrez Gene: CXCL11 chemokine (C-X-C motif) ligand 11". 
  2. ^ a b Cole KE, Strick CA, Paradis TJ, Ogborne KT, Loetscher M, Gladue RP, Lin W, Boyd JG, Moser B, Wood DE, Sahagan BG, Neote K (Jun 1998). "Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3". The Journal of Experimental Medicine 187 (12): 2009–21. doi:10.1084/jem.187.12.2009. PMC 2212354. PMID 9625760. 
  3. ^ Rani MR, Foster GR, Leung S, Leaman D, Stark GR, Ransohoff RM (Sep 1996). "Characterization of beta-R1, a gene that is selectively induced by interferon beta (IFN-beta) compared with IFN-alpha". The Journal of Biological Chemistry 271 (37): 22878–84. doi:10.1074/jbc.271.37.22878. PMID 8798467. 
  4. ^ Tensen CP, Flier J, Van Der Raaij-Helmer EM, Sampat-Sardjoepersad S, Van Der Schors RC, Leurs R, Scheper RJ, Boorsma DM, Willemze R (May 1999). "Human IP-9: A keratinocyte-derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3)". The Journal of Investigative Dermatology 112 (5): 716–22. doi:10.1046/j.1523-1747.1999.00581.x. PMID 10233762. 
  5. ^ Erdel M, Laich A, Utermann G, Werner ER, Werner-Felmayer G (1998). "The human gene encoding SCYB9B, a putative novel CXC chemokine, maps to human chromosome 4q21 like the closely related genes for MIG (SCYB9) and INP10 (SCYB10)". Cytogenetics and Cell Genetics 81 (3-4): 271–2. doi:10.1159/000015043. PMID 9730616. 
  6. ^ O'Donovan N, Galvin M, Morgan JG (1999). "Physical mapping of the CXC chemokine locus on human chromosome 4". Cytogenetics and Cell Genetics 84 (1-2): 39–42. doi:10.1159/000015209. PMID 10343098. 

Further reading[edit]

  • Rani MR, Foster GR, Leung S, Leaman D, Stark GR, Ransohoff RM (Sep 1996). "Characterization of beta-R1, a gene that is selectively induced by interferon beta (IFN-beta) compared with IFN-alpha". The Journal of Biological Chemistry 271 (37): 22878–84. doi:10.1074/jbc.271.37.22878. PMID 8798467. 
  • Jacobs KA, Collins-Racie LA, Colbert M, Duckett M, Golden-Fleet M, Kelleher K, Kriz R, LaVallie ER, Merberg D, Spaulding V, Stover J, Williamson MJ, McCoy JM (Oct 1997). "A genetic selection for isolating cDNAs encoding secreted proteins". Gene 198 (1-2): 289–96. doi:10.1016/S0378-1119(97)00330-2. PMID 9370294. 
  • Cole KE, Strick CA, Paradis TJ, Ogborne KT, Loetscher M, Gladue RP, Lin W, Boyd JG, Moser B, Wood DE, Sahagan BG, Neote K (Jun 1998). "Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3". The Journal of Experimental Medicine 187 (12): 2009–21. doi:10.1084/jem.187.12.2009. PMC 2212354. PMID 9625760. 
  • Erdel M, Laich A, Utermann G, Werner ER, Werner-Felmayer G (1998). "The human gene encoding SCYB9B, a putative novel CXC chemokine, maps to human chromosome 4q21 like the closely related genes for MIG (SCYB9) and INP10 (SCYB10)". Cytogenetics and Cell Genetics 81 (3-4): 271–2. doi:10.1159/000015043. PMID 9730616. 
  • Luo Y, Kim R, Gabuzda D, Mi S, Collins-Racie LA, Lu Z, Jacobs KA, Dorf ME (Dec 1998). "The CXC-chemokine, H174: expression in the central nervous system". Journal of Neurovirology 4 (6): 575–85. doi:10.3109/13550289809114224. PMID 10065899. 
  • Tensen CP, Flier J, Van Der Raaij-Helmer EM, Sampat-Sardjoepersad S, Van Der Schors RC, Leurs R, Scheper RJ, Boorsma DM, Willemze R (May 1999). "Human IP-9: A keratinocyte-derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3)". The Journal of Investigative Dermatology 112 (5): 716–22. doi:10.1046/j.1523-1747.1999.00581.x. PMID 10233762. 
  • Laich A, Meyer M, Werner ER, Werner-Felmayer G (May 1999). "Structure and expression of the human small cytokine B subfamily member 11 (SCYB11/formerly SCYB9B, alias I-TAC) gene cloned from IFN-gamma-treated human monocytes (THP-1)". Journal of Interferon & Cytokine Research 19 (5): 505–13. doi:10.1089/107999099313956. PMID 10386863. 
  • Tensen CP, Flier J, Rampersad SS, Sampat-Sardjoepersad S, Scheper RJ, Boorsma DM, Willemze R (Jul 1999). "Genomic organization, sequence and transcriptional regulation of the human CXCL 11(1) gene". Biochimica et Biophysica Acta 1446 (1-2): 167–72. doi:10.1016/s0167-4781(99)00084-6. PMID 10395932. 
  • Loetscher P, Pellegrino A, Gong JH, Mattioli I, Loetscher M, Bardi G, Baggiolini M, Clark-Lewis I (Feb 2001). "The ligands of CXC chemokine receptor 3, I-TAC, Mig, and IP10, are natural antagonists for CCR3". The Journal of Biological Chemistry 276 (5): 2986–91. doi:10.1074/jbc.M005652200. PMID 11110785. 
  • Lambeir AM, Proost P, Durinx C, Bal G, Senten K, Augustyns K, Scharpé S, Van Damme J, De Meester I (Aug 2001). "Kinetic investigation of chemokine truncation by CD26/dipeptidyl peptidase IV reveals a striking selectivity within the chemokine family". The Journal of Biological Chemistry 276 (32): 29839–45. doi:10.1074/jbc.M103106200. PMID 11390394. 
  • Hensbergen PJ, van der Raaij-Helmer EM, Dijkman R, van der Schors RC, Werner-Felmayer G, Boorsma DM, Scheper RJ, Willemze R, Tensen CP (Sep 2001). "Processing of natural and recombinant CXCR3-targeting chemokines and implications for biological activity". European Journal of Biochemistry / FEBS 268 (18): 4992–9. doi:10.1046/j.0014-2956.2001.02433.x. PMID 11559369. 
  • Mohan K, Ding Z, Hanly J, Issekutz TB (Jun 2002). "IFN-gamma-inducible T cell alpha chemoattractant is a potent stimulator of normal human blood T lymphocyte transendothelial migration: differential regulation by IFN-gamma and TNF-alpha". Journal of Immunology 168 (12): 6420–8. doi:10.4049/jimmunol.168.12.6420. PMID 12055261. 
  • Basu S, Schaefer TM, Ghosh M, Fuller CL, Reinhart TA (May 2002). "Molecular cloning and sequencing of 25 different rhesus macaque chemokine cDNAs reveals evolutionary conservation among C, CC, CXC, AND CX3C families of chemokines". Cytokine 18 (3): 140–8. doi:10.1006/cyto.2002.0875. PMID 12126650. 
  • Salmaggi A, Gelati M, Dufour A, Corsini E, Pagano S, Baccalini R, Ferrero E, Scabini S, Silei V, Ciusani E, De Rossi M (Jun 2002). "Expression and modulation of IFN-gamma-inducible chemokines (IP-10, Mig, and I-TAC) in human brain endothelium and astrocytes: possible relevance for the immune invasion of the central nervous system and the pathogenesis of multiple sclerosis". Journal of Interferon & Cytokine Research 22 (6): 631–40. doi:10.1089/10799900260100114. PMID 12162873. 
  • Rani MR, Hibbert L, Sizemore N, Stark GR, Ransohoff RM (Oct 2002). "Requirement of phosphoinositide 3-kinase and Akt for interferon-beta-mediated induction of the beta-R1 (SCYB11) gene". The Journal of Biological Chemistry 277 (41): 38456–61. doi:10.1074/jbc.M203204200. PMID 12169689. 
  • Kao J, Kobashigawa J, Fishbein MC, MacLellan WR, Burdick MD, Belperio JA, Strieter RM (Apr 2003). "Elevated serum levels of the CXCR3 chemokine ITAC are associated with the development of transplant coronary artery disease". Circulation 107 (15): 1958–61. doi:10.1161/01.CIR.0000069270.16498.75. PMID 12695288. 
  • Satish L, Yager D, Wells A (Jun 2003). "Glu-Leu-Arg-negative CXC chemokine interferon gamma inducible protein-9 as a mediator of epidermal-dermal communication during wound repair". The Journal of Investigative Dermatology 120 (6): 1110–7. doi:10.1046/j.1523-1747.2003.12230.x. PMID 12787142. 
  • Klunker S, Trautmann A, Akdis M, Verhagen J, Schmid-Grendelmeier P, Blaser K, Akdis CA (Jul 2003). "A second step of chemotaxis after transendothelial migration: keratinocytes undergoing apoptosis release IFN-gamma-inducible protein 10, monokine induced by IFN-gamma, and IFN-gamma-inducible alpha-chemoattractant for T cell chemotaxis toward epidermis in atopic dermatitis". Journal of Immunology 171 (2): 1078–84. doi:10.4049/jimmunol.171.2.1078. PMID 12847282. 
  • Xanthou G, Duchesnes CE, Williams TJ, Pease JE (Aug 2003). "CCR3 functional responses are regulated by both CXCR3 and its ligands CXCL9, CXCL10 and CXCL11". European Journal of Immunology 33 (8): 2241–50. doi:10.1002/eji.200323787. PMID 12884299.