CXCL15

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Cxcl15
Identifiers
Aliases chemokine (C-X-C motif) ligand 15Il8Scyb15lungkineweche
External IDs GeneCards: 20309
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_011339

n/a

RefSeq (protein)

NP_035469.1

n/a

Location (UCSC) n/a n/a
PubMed search [1] n/a
Wikidata
View/Edit Human

Chemokine (C-X-C motif) ligand 15 (CXCL15) is a small cytokine belonging to the CXC chemokine family that has been described in the mouse. This chemokine is also known under the name lungkine. CXCL15 is an ELR+ CXC chemokine (it contains the amino acid sequence E-L-R immediately before its CXC motif) that recruits neutrophils during inflammation of the lungs. It is highly abundant in epithelial cells of the lung,[1] and can also be found in other mucosal organs such as the urogenital and gastrointestinal tracts, and in endocrine organs like the adrenal gland.[2] The gene for CXCL15 is found on mouse chromosome 5.

References[edit]

  1. ^ Rossi D, Hurst S, Xu Y, Wang W, Menon S, Coffman R, Zlotnik A (1999). "Lungkine, a novel CXC chemokine, specifically expressed by lung bronchoepithelial cells". J Immunol 162 (9): 5490–7. PMID 10228029. 
  2. ^ Schmitz J, McCracken V, Dimmitt R, Lorenz R (2007). "Expression of CXCL15 (Lungkine) in Murine Gastrointestinal, Urogenital, and Endocrine Organs". J Histochem Cytochem 55 (5): 515–24. doi:10.1369/jhc.6A7121.2007. PMID 17242461.