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AliasesACKR3, CMKOR1, CXC-R7, CXCR-7, CXCR7, GPR159, RDC-1, RDC1, atypical chemokine receptor 3
External IDsOMIM: 610376 MGI: 109562 HomoloGene: 22419 GeneCards: ACKR3
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 2: 236.57 – 236.58 MbChr 1: 90.13 – 90.14 Mb
PubMed search[3][4]
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Atypical chemokine receptor 3 also known as C-X-C chemokine receptor type 7 (CXCR-7) and G-protein coupled receptor 159 (GPR159) is a protein that in humans is encoded by the ACKR3 gene.[5][6]

This gene encodes a member of the G protein-coupled receptor family. This protein was earlier thought to be a receptor for vasoactive intestinal peptide (VIP) and was considered to be an orphan receptor. It is now classified as a chemokine receptor able to bind the chemokines CXCL12/SDF-1 and CXCL11. The protein is also a coreceptor for human immunodeficiency viruses (HIV). Translocations involving this gene and HMGA2 on chromosome 12 have been observed in lipomas. Alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. Whereas some reports claim that the receptor induces signaling following ligand binding, recent findings in zebrafish suggest that CXCR7 functions primarily by sequestering the chemokine CXCL12.[6]

Another study has provided evidence that ligand binding to CXCR7 activates MAP kinases through Beta-arrestins, and thus has functions beyond ligand sequestration.[7]

ACKR3 has also been shown to sequester endogenous opioid peptides, and is thought to modulate their activity. Inhibition of ACKR3 by ligands such as the peptide LIH383 (FGGFMRRK-NH2) increases opioid peptide activity and produces analgesic and antidepressant effects in animal studies.[8]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000144476 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000044337 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Balabanian K, Lagane B, Infantino S, Chow KY, Harriague J, Moepps B, Arenzana-Seisdedos F, Thelen M, Bachelerie F (October 2005). "The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes". The Journal of Biological Chemistry. 280 (42): 35760–6. doi:10.1074/jbc.M508234200. PMID 16107333.
  6. ^ a b "Entrez Gene: CXCR7 chemokine (C-X-C motif) receptor 7".
  7. ^ * Rajagopal S, Kim J, Ahn S, Craig S, Lam CM, Gerard NP, Gerard C, Lefkowitz RJ (January 2010). "Beta-arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7". Proceedings of the National Academy of Sciences of the United States of America. 107 (2): 628–32. Bibcode:2010PNAS..107..628R. doi:10.1073/pnas.0912852107. PMC 2818968. PMID 20018651.
  8. ^ Meyrath M, Szpakowska M, Zeiner J, Massotte L, Merz MP, Benkel T, et al. (June 2020). "The atypical chemokine receptor ACKR3/CXCR7 is a broad-spectrum scavenger for opioid peptides". Nature Communications. 11 (1): 3033. Bibcode:2020NatCo..11.3033M. doi:10.1038/s41467-020-16664-0. PMC 7305236. PMID 32561830.

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.