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Aliases CYB561, cytochrome b561, CYB561A1, FRRS2
External IDs MGI: 103253 HomoloGene: 37552 GeneCards: CYB561
RNA expression pattern
PBB GE CYB561 207986 x at fs.png

PBB GE CYB561 210816 s at fs.png

PBB GE CYB561 209163 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 17: 63.43 – 63.45 Mb Chr 11: 105.93 – 105.95 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Cytochrome b561 is a protein that in humans is encoded by the CYB561 gene.[3][4]

Model organisms[edit]

Model organisms have been used in the study of CYB561 function. A conditional knockout mouse line, called Cyb561tm1a(EUCOMM)Wtsi[11][12] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[13][14][15]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[9][16] Twenty three tests were carried out on mutant mice and one significant abnormality was observed: female homozygotes displayed a decreased circulating glucose level after a glucose tolerance test.[9]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ McBride OW, Yi HF, Srivastava M (Nov 1994). "The human cytochrome b561 gene (CYB561) is located at 17q11-qter". Genomics. 21 (3): 662–3. PMID 7959749. doi:10.1006/geno.1994.1332. 
  4. ^ "Entrez Gene: CYB561 cytochrome b-561". 
  5. ^ "Dysmorphology data for Cyb561". Wellcome Trust Sanger Institute. 
  6. ^ "Glucose tolerance test data for Cyb561". Wellcome Trust Sanger Institute. 
  7. ^ "Salmonella infection data for Cyb561". Wellcome Trust Sanger Institute. 
  8. ^ "Citrobacter infection data for Cyb561". Wellcome Trust Sanger Institute. 
  9. ^ a b c Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. 
  10. ^ Mouse Resources Portal, Wellcome Trust Sanger Institute.
  11. ^ "International Knockout Mouse Consortium". 
  12. ^ "Mouse Genome Informatics". 
  13. ^ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. PMC 3572410Freely accessible. PMID 21677750. doi:10.1038/nature10163. 
  14. ^ Dolgin E (2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. PMID 21677718. doi:10.1038/474262a. 
  15. ^ Collins FS, Rossant J, Wurst W (2007). "A Mouse for All Reasons". Cell. 128 (1): 9–13. PMID 17218247. doi:10.1016/j.cell.2006.12.018. 
  16. ^ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism.". Genome Biol. 12 (6): 224. PMC 3218837Freely accessible. PMID 21722353. doi:10.1186/gb-2011-12-6-224. 

External links[edit]

Further reading[edit]