CYP26B1

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CYP26B1
Identifiers
Aliases CYP26B1, CYP26A2, P450RAI-2, P450RAI2, RHFCA, cytochrome P450 family 26 subfamily B member 1
External IDs MGI: 2176159 HomoloGene: 23179 GeneCards: CYP26B1
RNA expression pattern
PBB GE CYP26B1 219825 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001277742
NM_019885

NM_001177713
NM_175475

RefSeq (protein)

NP_001264671
NP_063938

NP_001171184
NP_780684

Location (UCSC) Chr 2: 72.13 – 72.15 Mb Chr 6: 84.57 – 84.59 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Cytochrome P450 26B1 is a protein that in humans is encoded by the CYP26B1 gene.[3][4]

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and the synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene is involved in the specific inactivation of all-trans-retinoic acid to hydroxylated forms, such as 4-oxo-, 4-OH-, and 18-OH-all-trans-retinoic acid.[4]

CYP26B1 has been shown to be over-expressed in colorectal cancer cells compared to normal colonic epithelium. CYP26B1 expression was also independently prognostic in patients with colorectal cancer and strong expression was associated with a poorer outcome.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Nelson DR (Dec 1999). "A second CYP26 P450 in humans and zebrafish: CYP26B1". Arch Biochem Biophys. 371 (2): 345–7. PMID 10545224. doi:10.1006/abbi.1999.1438. 
  4. ^ a b "Entrez Gene: CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1". 
  5. ^ Brown, Gordon; Beatriz Cash; Daniela Blihoghe; Petronella Johansson; Ayham Alnabulsi; Graeme Murray (2014-03-07). "The Expression and Prognostic Significance of Retinoic Acid Metabolising Enzymes in Colorectal Cancer". PLOS ONE. 9: e90776. PMC 3946526Freely accessible. PMID 24608339. doi:10.1371/journal.pone.0090776. 

External links[edit]

Further reading[edit]