CYP26C1

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CYP26C1
Identifiers
Aliases CYP26C1, FFDD4, cytochrome P450 family 26 subfamily C member 1
External IDs MGI: 2679699 HomoloGene: 28089 GeneCards: 340665
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_183374

NM_001105201

RefSeq (protein)

NP_899230.2

n/a

Location (UCSC) Chr 10: 93.06 – 93.07 Mb Chr 19: 37.69 – 37.69 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

CYP26C1 (cytochrome P450, family 26, subfamily c, polypeptide 1) is a protein which in humans is encoded by the CYP26C1 gene.[1]

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is involved in the catabolism of all-trans- and 9-cis-retinoic acid, and thus contributes to the regulation of retinoic acid levels in cells and tissues.[2]

CYP26C1 was found to show no expression in colorectal cancer cells or normal colonic epithelium.[3]

References[edit]

  1. ^ Taimi M, Helvig C, Wisniewski J, et al. (January 2004). "A novel human cytochrome P450, CYP26C1, involved in metabolism of 9-cis and all-trans isomers of retinoic acid". J. Biol. Chem. 279 (1): 77–85. doi:10.1074/jbc.M308337200. PMID 14532297. 
  2. ^ "Entrez Gene: CYP26C1". 
  3. ^ Brown, Gordon; Beatriz Cash; Daniela Blihoghe; Petronella Johansson; Ayham Alnabulsi; Graeme Murray (2014-03-07). "The Expression and Prognostic Significance of Retinoic Acid Metabolising Enzymes in Colorectal Cancer". PLOS ONE. doi:10.1371/journal.pone.0090776. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.