CYP2A7

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CYP2A7
Identifiers
AliasesCYP2A7, CPA7, CPAD, CYP2A, CYPIIA7, P450-IIA4, cytochrome P450 family 2 subfamily A member 7
External IDsMGI: 88597 HomoloGene: 85917 GeneCards: CYP2A7
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for CYP2A7
Genomic location for CYP2A7
Band19q13.2Start40,875,439 bp[1]
End40,882,752 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000764
NM_030589

NM_007812

RefSeq (protein)

NP_000755
NP_085079

n/a

Location (UCSC)Chr 19: 40.88 – 40.88 MbChr 7: 26.84 – 26.84 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CYP2A7 (cytochrome P450, family 2, subfamily A, polypeptide 7) is a protein that in humans is encoded by the CYP2A7 gene.[5][6]

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum; its substrate has not yet been determined. This gene, which produces two transcript variants, is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000198077 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000005547 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Fernandez-Salguero P, Hoffman SM, Cholerton S, Mohrenweiser H, Raunio H, Rautio A, Pelkonen O, Huang JD, Evans WE, Idle JR (September 1995). "A Genetic Polymorphism in Coumarin 7-Hydroxylation: Sequence of the Human CYP2A Gnes and Identification of Variant CYP2A6 Alleles". Am. J. Hum. Genet. 57 (3): 651–60. PMC 1801261Freely accessible. PMID 7668294. 
  6. ^ Nelson DR, Zeldin DC, Hoffman SM, Maltais LJ, Wain HM, Nebert DW (January 2004). "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants". Pharmacogenetics. 14 (1): 1–18. doi:10.1097/00008571-200401000-00001. PMID 15128046. 
  7. ^ "Entrez Gene: CYP2A7". 

External links[edit]

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.