Cytochrome P450 2B6 is an enzyme that in humans is encoded by the CYP2B6gene. CYP2B6 is a member of the cytochrome P450 group of enzymes. Along with CYP2A6, it is involved with metabolizing nicotine, along with many other substances.
This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide.
Transcript variants for this gene have been described; however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q.
^Alkattan, A., & Alsalameen, E. (2021). Polymorphisms of genes related to phase-I metabolic enzymes affecting the clinical efficacy and safety of clopidogrel treatment. Expert opinion on drug metabolism & toxicology, 10.1080/17425255.2021.1925249. Advance online publication. https://doi.org/10.1080/17425255.2021.1925249
^Meyer MR, Bach M, Welter J, Bovens M, Turcant A, Maurer HH (July 2013). "Ketamine-derived designer drug methoxetamine: metabolism including isoenzyme kinetics and toxicological detectability using GC-MS and LC-(HR-)MSn". Analytical and Bioanalytical Chemistry. 405 (19): 6307–21. doi:10.1007/s00216-013-7051-6. PMID23774830. S2CID27966043.
^Obach RS, Cox LM, Tremaine LM (February 2005). "Sertraline is metabolized by multiple cytochrome P450 enzymes, monoamine oxidases, and glucuronyl transferases in human: an in vitro study". Drug Metabolism and Disposition. 33 (2): 262–70. doi:10.1124/dmd.104.002428. PMID15547048. S2CID7254643.
^Phillips BG, Gandhi AJ, Sanoski CA, Just VL, Bauman JL (1997). "Comparison of intravenous diltiazem and verapamil for the acute treatment of atrial fibrillation and atrial flutter". Pharmacotherapy. 17 (6): 1238–45. PMID9399606.
^Guo Z, Raeissi S, White RB, Stevens JC (March 1997). "Orphenadrine and methimazole inhibit multiple cytochrome P450 enzymes in human liver microsomes". Drug Metabolism and Disposition. 25 (3): 390–3. PMID9172960.
^Appiah-Opong R, Commandeur JN, van Vugt-Lussenburg B, Vermeulen NP (June 2007). "Inhibition of human recombinant cytochrome P450s by curcumin and curcumin decomposition products". Toxicology. 235 (1–2): 83–91. doi:10.1016/j.tox.2007.03.007. PMID17433521.
^ abcdeHesse LM, Venkatakrishnan K, Court MH, von Moltke LL, Duan SX, Shader RI, Greenblatt DJ (October 2000). "CYP2B6 mediates the in vitro hydroxylation of bupropion: potential drug interactions with other antidepressants". Drug Metabolism and Disposition. 28 (10): 1176–83. PMID10997936.
Ngaimisi E, Mugusi S, Minzi OM, Sasi P, Riedel KD, Suda A, Ueda N, Janabi M, Mugusi F, Haefeli WE, Burhenne J, Aklillu E (November 2010). "Long-term efavirenz autoinduction and its effect on plasma exposure in HIV patients". Clinical Pharmacology and Therapeutics. 88 (5): 676–84. doi:10.1038/clpt.2010.172. PMID20881953. S2CID24749169.
Smith G, Stubbins MJ, Harries LW, Wolf CR (December 1998). "Molecular genetics of the human cytochrome P450 monooxygenase superfamily". Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 28 (12): 1129–65. doi:10.1080/004982598238868. PMID9890157.
Svärd J, Spiers JP, Mulcahy F, Hennessy M (December 2010). "Nuclear receptor-mediated induction of CYP450 by antiretrovirals: functional consequences of NR1I2 (PXR) polymorphisms and differential prevalence in whites and sub-Saharan Africans". Journal of Acquired Immune Deficiency Syndromes. 55 (5): 536–49. doi:10.1097/QAI.0b013e3181f52f0c. PMID20861742. S2CID205996665.
Melanson SE, Stevenson K, Kim H, Antin JH, Court MH, Ho VT, Ritz J, Soiffer RJ, Kuo FC, Longtine JA, Jarolim P (December 2010). "Allelic variations in CYP2B6 and CYP2C19 and survival of patients receiving cyclophosphamide prior to myeloablative hematopoietic stem cell transplantation". American Journal of Hematology. 85 (12): 967–71. doi:10.1002/ajh.21889. PMID21108329. S2CID25737167.
Nelson DR, Zeldin DC, Hoffman SM, Maltais LJ, Wain HM, Nebert DW (January 2004). "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants". Pharmacogenetics. 14 (1): 1–18. doi:10.1097/00008571-200401000-00001. PMID15128046.
Mo SL, Liu YH, Duan W, Wei MQ, Kanwar JR, Zhou SF (September 2009). "Substrate specificity, regulation, and polymorphism of human cytochrome P450 2B6". Current Drug Metabolism. 10 (7): 730–53. doi:10.2174/138920009789895534. PMID19702527.
Cabrera Figueroa S, Fernández de Gatta M, Hernández García L, Domínguez-Gil Hurlé A, Bustos Bernal C, Sepúlveda Correa R, García Sánchez MJ (October 2010). "The convergence of therapeutic drug monitoring and pharmacogenetic testing to optimize efavirenz therapy". Therapeutic Drug Monitoring. 32 (5): 579–85. doi:10.1097/FTD.0b013e3181f0634c. PMID20720517. S2CID24793535.
Shimada M, Miyagawa T, Kawashima M, Tanaka S, Honda Y, Honda M, Tokunaga K (October 2010). "An approach based on a genome-wide association study reveals candidate loci for narcolepsy". Human Genetics. 128 (4): 433–41. doi:10.1007/s00439-010-0862-z. PMID20677014. S2CID24207887.
Lindfelt T, O'Brien J, Song JC, Patel R, Winslow DL (October 2010). "Efavirenz plasma concentrations and cytochrome 2B6 polymorphisms". The Annals of Pharmacotherapy. 44 (10): 1572–8. doi:10.1345/aph.1P141. PMID20841522. S2CID24188775.
Chung JY, Cho JY, Lim HS, Kim JR, Yu KS, Lim KS, Shin SG, Jang IJ (January 2011). "Effects of pregnane X receptor (NR1I2) and CYP2B6 genetic polymorphisms on the induction of bupropion hydroxylation by rifampin". Drug Metabolism and Disposition. 39 (1): 92–7. doi:10.1124/dmd.110.035246. PMID20876786. S2CID15380723.
Lampreabe I, Gainza de los Rios FJ, Arrieta Gutiérrez A, Jofre-Monseny L, Rodriguez M, Amenabar Iribar JJ, Zárraga Larrondo S, Tejedor D, Martinez A, Olano-Martin E (October 2010). "Toward personalized medicine in renal transplantation". Transplantation Proceedings. 42 (8): 2864–7. doi:10.1016/j.transproceed.2010.08.009. PMID20970553.
Elens L, Vandercam B, Yombi JC, Lison D, Wallemacq P, Haufroid V (September 2010). "Influence of host genetic factors on efavirenz plasma and intracellular pharmacokinetics in HIV-1-infected patients". Pharmacogenomics. 11 (9): 1223–34. doi:10.2217/pgs.10.94. PMID20860463.