This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum but its specific substrate has not yet been determined. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. An additional gene, CYP2C17, was once thought to exist; however, CYP4217 is now considered an artefact based on a chimera of CYP2C18 and CYP2C19.
^Furuya H, Meyer UA, Gelboin HV, Gonzalez FJ (Oct 1991). "Polymerase chain reaction-directed identification, cloning, and quantification of human CYP2C18 mRNA". Mol Pharmacol40 (3): 375–82. PMID1896026.
^Romkes M, Faletto MB, Blaisdell JA, Raucy JL, Goldstein JA (May 1991). "Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily". Biochemistry30 (13): 3247–55. doi:10.1021/bi00227a012. PMID2009263.
Romkes M, Faletto MB, Blaisdell JA; et al. (1993). "Cloning and expression of complementary DNAs for multiple members of the human cytochrome PH50IIC subfamily". Biochemistry32 (5): 1390. doi:10.1021/bi00056a025. PMID8095407.
Goldstein JA, Faletto MB, Romkes-Sparks M; et al. (1994). "Evidence that CYP2C19 is the major (S)-mephenytoin 4'-hydroxylase in humans". Biochemistry33 (7): 1743–52. doi:10.1021/bi00173a017. PMID8110777.
de Morais SM, Schweikl H, Blaisdell J, Goldstein JA (1993). "Gene structure and upstream regulatory regions of human CYP2C9 and CYP2C18". Biochem. Biophys. Res. Commun.194 (1): 194–201. doi:10.1006/bbrc.1993.1803. PMID8333835.
Richardson TH, Griffin KJ, Jung F; et al. (1997). "Targeted antipeptide antibodies to cytochrome P450 2C18 based on epitope mapping of an inhibitory monoclonal antibody to P450 2C51". Arch. Biochem. Biophys.338 (2): 157–64. doi:10.1006/abbi.1996.9817. PMID9028867.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID9373149.
Macé K, Bowman ED, Vautravers P; et al. (1998). "Characterisation of xenobiotic-metabolising enzyme expression in human bronchial mucosa and peripheral lung tissues". Eur. J. Cancer34 (6): 914–20. doi:10.1016/S0959-8049(98)00034-3. PMID9797707.
Marill J, Cresteil T, Lanotte M, Chabot GG (2001). "Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites". Mol. Pharmacol.58 (6): 1341–8. PMID11093772.
Zhu-Ge J, Yu YN, Qian YL, Li X (2003). "Establishment of a transgenic cell line stably expressing human cytochrome P450 2C18 and identification of a CYP2C18 clone with exon 5 missing". World J. Gastroenterol.8 (5): 888–92. PMID12378636.