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Cytochrome P450, family 2, subfamily C, polypeptide 18
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CYP2C18 ; CPCI; CYP2C; CYP2C17; P450-6B/29C; P450IIC17
External IDs OMIM601131 MGI1919332 HomoloGene133567 ChEMBL: 2408 GeneCards: CYP2C18 Gene
EC number
RNA expression pattern
PBB GE CYP2C18 208126 s at tn.png
PBB GE CYP2C18 215103 at tn.png
More reference expression data
Species Human Mouse
Entrez 1562 72082
Ensembl ENSG00000108242 ENSMUSG00000025002
UniProt P33260 Q9D816
RefSeq (mRNA) NM_000772 NM_028089
RefSeq (protein) NP_000763 NP_082365
Location (UCSC) Chr 10:
94.68 – 94.74 Mb
Chr 19:
39.01 – 39.04 Mb
PubMed search [1] [2]

Cytochrome P450 2C18 is a protein that in humans is encoded by the CYP2C18 gene.[1][2][3]

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum but its specific substrate has not yet been determined. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. An additional gene, CYP2C17, was once thought to exist; however, CYP4217 is now considered an artefact based on a chimera of CYP2C18 and CYP2C19.[3]


  1. ^ Furuya H, Meyer UA, Gelboin HV, Gonzalez FJ (Oct 1991). "Polymerase chain reaction-directed identification, cloning, and quantification of human CYP2C18 mRNA". Mol Pharmacol 40 (3): 375–82. PMID 1896026. 
  2. ^ Romkes M, Faletto MB, Blaisdell JA, Raucy JL, Goldstein JA (May 1991). "Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily". Biochemistry 30 (13): 3247–55. doi:10.1021/bi00227a012. PMID 2009263. 
  3. ^ a b "Entrez Gene: CYP2C18 cytochrome P450, family 2, subfamily C, polypeptide 18". 

Further reading[edit]