CYP39A1

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CYP39A1
Identifiers
AliasesCYP39A1, cytochrome P450 family 39 subfamily A member 1
External IDsMGI: 1927096 HomoloGene: 9580 GeneCards: CYP39A1
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for CYP39A1
Genomic location for CYP39A1
Band6p12.3Start46,549,580 bp[1]
End46,652,830 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001278738
NM_001278739
NM_016593

NM_001285947
NM_001285948
NM_018887

RefSeq (protein)

NP_001265667
NP_001265668
NP_057677

NP_001272876
NP_001272877
NP_061375

Location (UCSC)Chr 6: 46.55 – 46.65 MbChr 17: 43.67 – 43.75 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CYP39A1 (cytochrome P450, family 39, subfamily A, polypeptide 1) also known as oxysterol 7-α-hydroxylase 2 is a protein that in humans is encoded by the CYP39A1 gene.[5]

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is involved in the conversion of cholesterol to bile acids. Its substrates include the oxysterols 24-hydroxycholesterol, 25-hydroxycholesterol and 27-hydroxycholesterol.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000146233 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023963 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Li-Hawkins J, Lund EG, Bronson AD, Russell DW (June 2000). "Expression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterol". J. Biol. Chem. 275 (22): 16543–9. doi:10.1074/jbc.M001810200. PMID 10748047. 
  6. ^ "Entrez Gene: CYP39A1". 

External links[edit]

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.