CYP3A43

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CYP3A43
Available structures
PDB Human UniProt search: PDBe RCSB
Identifiers
Aliases CYP3A43
External IDs HomoloGene: 136124 GeneCards: 64816
EC number 1.14.13.157
RNA expression pattern
PBB GE CYP3A43 207773 x at tn.png

PBB GE CYP3A43 211440 x at tn.png

PBB GE CYP3A43 211441 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001278921
NM_022820
NM_057095
NM_057096

n/a

RefSeq (protein)

NP_001265850.1
NP_073731.1
NP_476436.1
NP_476437.1

n/a

Location (UCSC) Chr 7: 99.83 – 99.87 Mb n/a
PubMed search [1] n/a
Wikidata
View/Edit Human

Cytochrome P450 3A43 is a protein that in humans is encoded by the CYP3A43 gene.[2][3][4]

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme has a low level of testosterone hydroxylase activity. Although it bears homology to some drug-metabolizing cytochrome P450s, it is unknown whether the enzyme is also involved in xenobiotic metabolism. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Alternate splicing of this gene results in three transcript variants encoding different isoforms.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ Domanski TL, Finta C, Halpert JR, Zaphiropoulos PG (Feb 2001). "cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome P450". Mol Pharmacol. 59 (2): 386–92. PMID 11160876. 
  3. ^ Gellner K, Eiselt R, Hustert E, Arnold H, Koch I, Haberl M, Deglmann CJ, Burk O, Buntefuss D, Escher S, Bishop C, Koebe HG, Brinkmann U, Klenk HP, Kleine K, Meyer UA, Wojnowski L (Mar 2001). "Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene". Pharmacogenetics. 11 (2): 111–21. doi:10.1097/00008571-200103000-00002. PMID 11266076. 
  4. ^ a b "Entrez Gene: CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43". 

Further reading[edit]