CYP8B1 (cytochrome P450, family 8, subfamily B, polypeptide 1) also known as sterol 12-alpha-hydroxylase is a protein which in humans is encoded by the CYP8B1gene.
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.
^Gåfvels M, Olin M, Chowdhary BP, Raudsepp T, Andersson U, Persson B, Jansson M, Björkhem I, Eggertsen G (March 1999). "Structure and chromosomal assignment of the sterol 12alpha-hydroxylase gene (CYP8B1) in human and mouse: eukaryotic cytochrome P-450 gene devoid of introns". Genomics56 (2): 184–96. doi:10.1006/geno.1998.5606. PMID10051404.
Li Y, Mezei O, Shay NF (2007). "Human and murine hepatic sterol-12-alpha-hydroxylase and other xenobiotic metabolism mRNA are upregulated by soy isoflavones.". J. Nutr.137 (7): 1705–12. PMID17585019.
Yang Y, Eggertsen G, GÃ¥fvels M et al. (2004). "Mechanisms of cholesterol and sterol regulatory element binding protein regulation of the sterol 12alpha-hydroxylase gene (CYP8B1).". Biochem. Biophys. Res. Commun.320 (4): 1204–10. doi:10.1016/j.bbrc.2004.06.069. PMID15249218.
Ellis EC (2006). "Suppression of bile acid synthesis by thyroid hormone in primary human hepatocytes.". World J. Gastroenterol.12 (29): 4640–5. PMID16937432.
Wang J, Greene S, Eriksson LC et al. (2005). "Human sterol 12a-hydroxylase (CYP8B1) is mainly expressed in hepatocytes in a homogenous pattern.". Histochem. Cell Biol.123 (4-5): 441–6. doi:10.1007/s00418-005-0779-0. PMID15891895.
Nelson DR, Zeldin DC, Hoffman SM et al. (2004). "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants.". Pharmacogenetics14 (1): 1–18. doi:10.1097/00008571-200401000-00001. PMID15128046.
Zhang M, Chiang JY (2001). "Transcriptional regulation of the human sterol 12alpha-hydroxylase gene (CYP8B1): roles of heaptocyte nuclear factor 4alpha in mediating bile acid repression.". J. Biol. Chem.276 (45): 41690–9. doi:10.1074/jbc.M105117200. PMID11535594.