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Ca2+/calmodulin-dependent protein kinase
EC number2.7.11.17
CAS number97350-82-8
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

CAMK, also written as CaMK, is an abbreviation for the Ca2+/calmodulin-dependent protein kinase class of enzymes. CAMKs are activated by increases in the concentration of intracellular calcium ions (Ca2+) and calmodulin. When activated, the enzymes transfer phosphates from ATP to defined serine or threonine residues in other proteins, so they are serine/threonine-specific protein kinases. Activated CAMK is involved in the phosphorylation of transcription factors and therefore, in the regulation of expression of responding genes. Members of this enzyme class include:


Pseudokinases are pseudoenzymes, and don't have any enzymatic activity. Some are related to CAMK:


  1. ^ Haribabu B, Hook SS, Selbert MA, Goldstein EG, Tomhave ED, Edelman AM, Snyderman R, Means AR (Sep 1995). "Human calcium-calmodulin dependent protein kinase I: cDNA cloning, domain structure and activation by phosphorylation at threonine-177 by calcium-calmodulin dependent protein kinase I kinase". EMBO J. 14 (15): 3679–86. PMC 394442. PMID 7641687.
  2. ^ a b "Entrez Gene: CAMK1 calcium/calmodulin-dependent protein kinase I".
  3. ^ Yamauchi, Takashi (2005). "Neuronal Ca2+/Calmodulin-Dependent Protein Kinase II—Discovery, Progress in a Quarter of a Century, and Perspective: Implication for Learning and Memory". Biological & Pharmaceutical Bulletin. 28 (8): 1342–54. doi:10.1248/bpb.28.1342. PMID 16079472.
  4. ^ "Calmodulin dependent protein kinases (CAMK)". HUGO Gene Nomenclature Committee.
  5. ^ Chen, Fei; Zhang, Liangsheng; Lin, Zhenguo; Cheng, Zong-Ming Max (2018). "Identification of a novel fused gene family implicates convergent evolution in eukaryotic calcium signaling". BMC Genomics. 19 (1). doi:10.1186/s12864-018-4685-y. ISSN 1471-2164.