Cadherin cytoplasmic region

From Wikipedia, the free encyclopedia
Jump to: navigation, search
PDB 1i7x EBI.jpg
beta-catenin/e-cadherin complex
Symbol Cadherin_C
Pfam PF01049
InterPro IPR000233
SCOP 1i7w

In molecular biology, the cadherin cytoplasmic region is a conserved region found at the C-terminus of cadherin proteins. A key determinant to the strength of the binding that it is mediated by cadherins is the juxtamembrane region (the part of the cytoplasmic region which is adjacent to the transmembrane domain) of the cadherin. This region induces clustering and also binds to the protein catenin (p120ctn).[1] The cytoplasmic region is highly conserved in sequence and has been shown experimentally to regulate the cell-cell binding function of the extracellular domain of E-cadherin, possibly through interaction with the cytoskeleton.[2]


This article incorporates text from the public domain Pfam and InterPro IPR000233