2-hydroxy-1,2,3-propane- tricarboxylic acid calcium salt (2:3)
|Jmol interactive 3D||Image|
|Molar mass||498.4334 g/mol (anhydrous)
570.49452 g/mol (tetrahydrate)
|Density||1.63 g/cm3, solid|
|Melting point||120 °C (248 °F; 393 K) (loses water)|
|0.085 g/100 mL (18 °C)
0.095 g/100 mL (25 °C)
|Solubility||insoluble in alcohol|
|Safety data sheet||External MSDS|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|what is ?)(|
Calcium citrate is the calcium salt of citric acid. It is commonly used as a food additive (E333), usually as a preservative, but sometimes for flavor. In this sense, it is similar to sodium citrate. Calcium citrate is also found in some dietary calcium supplements (e.g. Citracal). Calcium makes up 24.1% of calcium citrate (anhydrous) and 21.1% of calcium citrate (tetrahydrate) by mass.
Calcium citrate is is insoluble in water. Needle-shaped crystals of [Ca3(C6H5O7)2(H2O)2]·2H2O were obtained by hydrothermal synthesis. The crystal structure comprises a three-dimensional network in which eightfold coordinated Ca2+ cations are linked by citrate anions and hydrogen bonds between two non-coordinating crystal water molecules and two coordinating water molecules.
Calcium citrate is an intermediate in the isolation of citric acid from the fermentation process by which citric acid is produced industrially. The citric acid in the broth solution is neutralized by calcium hydroxide, precipitating insoluble calcium citrate. This is then filtered off from the rest of the broth and washed to give clean calcium citrate.
- 3Ca(OH)2(s) + 2C6H8O7(l) → Ca3(C6H5O7)2(s) + 6H2O(l)
The calcium citrate thus produced may be sold as-is, or it may be converted to citric acid using dilute sulfuric acid.
Calcium Citrate can be used as a calcium supplement, in acidic or slightly acidic beverages and juices, milk products and other nutritional supplements. It can also be used in Food Industry.
In many individuals, bioavailability of calcium citrate is found to be equal to that of the cheaper calcium carbonate. However, alterations to the digestive tract may change how calcium is digested and absorbed. Unlike calcium carbonate, which is basic and neutralizes stomach acid, calcium citrate has no effect on stomach acid. Calcium carbonate is harder to digest than calcium citrate, and calcium carbonate carries a risk of "acid rebound" (the stomach overcompensates by producing more acid), so individuals who are sensitive to antacids or who have difficulty producing adequate stomach acid may choose calcium citrate over calcium carbonate for supplementation. According to recent research into calcium absorption after gastric bypass surgery, calcium citrate may have improved bioavailability over calcium carbonate in Roux-en-Y gastric bypass patients who are taking calcium citrate as a dietary supplement after surgery. This is mainly due to the changes related to where calcium absorption occurs in the digestive tract of these individuals.
- Herdtweck, Eberhardt; Kornprobst, Tobias; Sieber, Roland; Straver, Leo; Plank, Johann (2011). "Crystal Structure, Synthesis, and Properties of tri-Calcium di-Citrate tetra-Hydrate [Ca3(C6H5O7)2(H2O)2]·2H2O". Z. Anorg. Allgemeine Chemie 637 (6): 655–659. doi:10.1002/zaac.201100088.
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- Heaney RP, Dowell MS, Bierman J, Hale CA, Bendich A (June 2001). "Absorbability and cost effectiveness in calcium supplementation". Journal of the American College of Nutrition 20 (3): 239–46. doi:10.1080/07315724.2001.10719038. PMID 11444420. Retrieved 2009-11-03.| PMID 11444420
- "What you need to know about calcium". Harvard Health Publications. Retrieved 4 August 2014.
- Tondapu, P. and Provost, D. and Adams-Huet, B. and Sims, T. and Chang, C. and Sakhaee, K. (June 2009). "Comparison of the Absorption of Calcium Carbonate and Calcium Citrate after Roux-en-Y Gastric Bypass". Obesity Surgery 19 (9): 1256–1261. doi:10.1007/s11695-009-9850-6. PMID 19437082. Retrieved 2010-08-11.