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Calgranulin is an S100 calcium-binding protein that is expressed in multiple cell types, including renal epithelial cells and neutrophils.

The proteins S100A8 and S100A9 form a heterodimer called calprotectin.

Human genes[edit]


Some in vitro evidence suggests that calgranulin can inhibit the precipitation of calcium oxalate in a urine-like environment at calgranulin concentrations below physiological concentrations.[1] Thus, it may also function in vivo as an inhibitor of calcium oxalate kidney stone formation. However, the role of calgranulin in the stone formation process has not been evaluated.


  1. ^ Pillay S, Asplin J, Coe F (1 August 1998). "Evidence that calgranulin is produced by kidney cells and is an inhibitor of calcium oxalate crystallization". Am J Physiol 275 (2 Pt 2): F255–61. PMID 9691016. 

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