"Can't Nobody Hold Me Down" is the debut hit single by rapper Sean "Puff Daddy" Combs. It appears on Combs' debut album No Way Out and it was released as the first single in 1997.
The song entered the U.S. Billboard Hot 100 at number thirty-two in early 1997 and eventually spent six weeks at number one. It was the beginning of Combs' and Bad Boy Records' chart domination during the year — the Combs-produced "Hypnotize" by The Notorious B.I.G. would follow this song at number one, and the B.I.G. tribute song "I'll Be Missing You" spent eleven weeks at number one during the summer, only to be followed by another B.I.G. song, "Mo Money Mo Problems" and then the Combs-produced "Honey" by Mariah Carey.
Combs was already a successful songwriter, producer and record label owner (Bad Boy Records) before he released his debut album as a performer. His first U.S. chart single, "No Time", was a top-twenty hit for Lil' Kim on which Puff Daddy was credited as a featured vocalist. "Can't Nobody Hold Me Down" was the debut chart appearance for Harlem-based rapper Mase.