Can f 1

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Can f 1 or canis familiaris allergen 1 is a lipocalin[1] allergen produced by dogs[2] in their tongue epithelial tissue.[3] It is homologous with the human lipocalin LCN1.[4][5]


  1. ^ Major allergen Can f 1 UniProtKB.
  2. ^ Grammer, Leslie C. and Paul A. Greenberger (2009), Patterson's Allergic Diseases p. 97.
  3. ^ Konieczny, A; Morgenstern, J P; Bizinkauskas, C B; Lilley, C H; Brauer, A W; Bond, J F; Aalberse, R C; Wallner, B P; Kasaian, M T (December 1997). "The major dog allergens, Can f 1 and Can f 2, are salivary lipocalin proteins: cloning and immunological characterization of the recombinant forms". Immunology. 92 (4): 577–586. ISSN 0019-2805. PMC 1364166. PMID 9497502.
  4. ^ Jensen‐Jarolim, E.; Pacios, L.F.; Bianchini, R.; Hofstetter, G.; Roth‐Walter, F. (March 2016). "Structural similarities of human and mammalian lipocalins, and their function in innate immunity and allergy". Allergy. 71 (3): 286–294. doi:10.1111/all.12797. ISSN 0105-4538. PMC 4949658. PMID 26497994.
  5. ^ Breitenbuecher, Christina; Belanger, Janelle M.; Levy, Kerinne; Mundell, Paul; Fates, Valerie; Gershony, Liza; Famula, Thomas R.; Oberbauer, Anita M. (2016-04-22). "Protein expression and genetic variability of canine Can f 1 in golden and Labrador retriever service dogs". Canine Genetics and Epidemiology. 3. doi:10.1186/s40575-016-0031-3. ISSN 2052-6687. PMC 4840867. PMID 27110374.