On 27 August 1972, Douglas C-47 YV-C-AKE of LAV suffered a failure of the port engine shortly after take-off on a domestic scheduled passenger flight to Tomás de Heres Airport, Ciudad Bolivar. The aircraft crashed while attempting to return to Canaima, killing all 34 people on board.
On 2 October 1998, Douglas DC-3C YV-611C of Servivensa crashed on approach to Canaima Airport. The aircraft had been on a local sightseeing flight to view the Angel Falls. One of the 25 people on board was killed.