Canapitsit Channel is a channel that separates Nashawena Island from Cuttyhunk Island, two of the Elizabeth Islands off Cape Cod, Massachusetts. It is one of four straits allowing maritime passage between Buzzards Bay and the Vineyard Sound. The others are Quick's Hole, Robinson's Hole and Woods Hole.
Strong tidal currents (up to 6 knots) separate the islands from each other. The currents are driven by the different sizes and filling rates of Vineyard Sound to the southeast and Buzzards Bay to the northwest.