Carbonic anhydrase VI

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CA6
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCA6, CA-VI, GUSTIN, carbonic anhydrase 6
External IDsOMIM: 114780 MGI: 1333786 HomoloGene: 20324 GeneCards: CA6
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001215
NM_001270500
NM_001270501
NM_001270502

NM_009802

RefSeq (protein)

NP_001206
NP_001257429
NP_001257430
NP_001257431

NP_033932

Location (UCSC)Chr 1: 8.95 – 8.98 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Carbonic anhydrase 6 is an enzyme that in humans is encoded by the CA6 gene.[4][5] It is also called 'gustin' because of its presence in saliva, and lower-than-normal levels of salivary zinc in individuals with hypogeusia.[6][7]

Function[edit]

The protein encoded by this gene is one of several isozymes of carbonic anhydrase. This protein is abundantly found in salivary glands and saliva and protein may play a role in the reversible hydratation of carbon dioxide, though its function in saliva is unknown.[5]

It has been suggested that CA VI participates in the maintenance of appropriate pH homeostasis on tooth surfaces as well as in the mucosa of the gastrointestinal canal.

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000131686 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ White PS, Jensen SJ, Rajalingam V, Stairs D, Sulman EP, Maris JM, Biegel JA, Wooster R, Brodeur GM (Oct 1998). "Physical mapping of the CA6, ENO1, and SLC2A5 (GLUT5) genes and reassignment of SLC2A5 to 1p36.2". Cytogenetics and Cell Genetics. 81 (1): 60–4. doi:10.1159/000014989. PMID 9691177. S2CID 46770845.
  5. ^ a b "Entrez Gene: CA6 carbonic anhydrase VI".
  6. ^ Henkin RI, Mueller CW, Wolf RO (July 1975). "Estimation of zinc concentration of parotid saliva by flameless atomic absorption spectrophotometry in normal subjects and in patients with idiopathic hypogeusia". The Journal of Laboratory and Clinical Medicine. 86 (1): 175–80. PMID 1151138.
  7. ^ Henkin RI, Lippoldt RE, Bilstad J, Edelhoch H (February 1975). "A zinc protein isolated from human parotid saliva". Proceedings of the National Academy of Sciences of the United States of America. 72 (2): 488–92. Bibcode:1975PNAS...72..488H. doi:10.1073/pnas.72.2.488. PMC 432337. PMID 1054831.

Further reading[edit]