Carbonic anhydrase VI

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Carbonic anhydrase VI
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CA6 ; CA-VI; GUSTIN
External IDs OMIM114780 MGI1333786 HomoloGene20324 ChEMBL: 3025 GeneCards: CA6 Gene
EC number
RNA expression pattern
PBB GE CA6 206873 at tn.png
More reference expression data
Species Human Mouse
Entrez 765 12353
Ensembl ENSG00000131686 ENSMUSG00000028972
UniProt P23280 P18761
RefSeq (mRNA) NM_001215 NM_009802
RefSeq (protein) NP_001206 NP_033932
Location (UCSC) Chr 1:
8.95 – 8.98 Mb
Chr 4:
150.19 – 150.2 Mb
PubMed search [1] [2]

Carbonic anhydrase 6 (also called 'Gustin') is an enzyme that in humans is encoded by the CA6 gene.[1][2]

The protein encoded by this gene is one of several isozymes of carbonic anhydrase. This protein is abundantly found in salivary glands and saliva and protein may play a role in the reversible hydratation of carbon dioxide, though its function in saliva is unknown.[2] It has been suggested that CA VI participates in the maintenance of appropriate pH homeostasis on tooth surfaces as well as in the mucosa of the gastrointestinal canal.


  1. ^ White PS, Jensen SJ, Rajalingam V, Stairs D, Sulman EP, Maris JM, Biegel JA, Wooster R, Brodeur GM (Oct 1998). "Physical mapping of the CA6, ENO1, and SLC2A5 (GLUT5) genes and reassignment of SLC2A5 to 1p36.2". Cytogenet Cell Genet 81 (1): 60–4. doi:10.1159/000014989. PMID 9691177. 
  2. ^ a b "Entrez Gene: CA6 carbonic anhydrase VI". 

Further reading[edit]