CA14

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  (Redirected from Carbonic anhydrase XIV)
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CA14
4lu3.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CA14, CAXiV, carbonic anhydrase 14
External IDs MGI: 1344341 HomoloGene: 69105 GeneCards: CA14
RNA expression pattern
PBB GE CA14 219464 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_012113

NM_011797

RefSeq (protein)

NP_036245

NP_035927.1
NP_035927

Location (UCSC) Chr 1: 150.26 – 150.27 Mb Chr 3: 95.9 – 95.9 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Carbonic anhydrase 14 is an enzyme that in humans is encoded by the CA14 gene.[3][4]

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XIV is predicted to be a type I membrane protein and shares highest sequence similarity with the other transmembrane CA isoform, CA XII; however, they have different patterns of tissue-specific expression and thus may play different physiologic roles.[4]

In melanocytic cells CA14 gene expression may be regulated by MITF.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Fujikawa-Adachi K, Nishimori I, Taguchi T, Onishi S (Nov 1999). "Human carbonic anhydrase XIV (CA14): cDNA cloning, mRNA expression, and mapping to chromosome 1". Genomics. 61 (1): 74–81. doi:10.1006/geno.1999.5938. PMID 10512682. 
  4. ^ a b "Entrez Gene: CA14 carbonic anhydrase XIV". 
  5. ^ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. 

External links[edit]

Further reading[edit]