Carboxylesterase 2

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CES2
Identifiers
AliasesCES2, CE-2, CES2A1, PCE-2, iCE, Carboxylesterase 2
External IDsOMIM: 605278 MGI: 3648740 HomoloGene: 128645 GeneCards: CES2
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for CES2
Genomic location for CES2
Band16q22.1Start66,934,444 bp[1]
End66,945,096 bp[1]
RNA expression pattern
PBB GE CES2 209667 at fs.png

PBB GE CES2 209668 x at fs.png

PBB GE CES2 213509 x at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001272045

RefSeq (protein)

NP_001258974

Location (UCSC)Chr 16: 66.93 – 66.95 MbChr 8: 105 – 105.02 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Carboxylesterase 2 is an enzyme that in humans is encoded by the CES2 gene.[5][6][7] It is a member of the alpha/beta fold hydrolase family.[8]

Carboxylesterase 2 is a member of a large multigene family. The enzymes encoded by these genes are responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and heroin. They also hydrolyze long-chain fatty acid esters and thioesters. The specific function of this enzyme has not yet been determined; however, it is speculated that carboxylesterases may play a role in lipid metabolism and/or the blood–brain barrier system. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[7]

Interactive pathway map[edit]

Click on genes, proteins and metabolites below to link to respective articles.[§ 1]
[[File:
FluoropyrimidineActivity_WP1601go to articlego to articlego to articlego to pathway articlego to pathway articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to PubChem Compoundgo to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to pathway articlego to pathway articlego to articlego to articlego to articlego to articlego to articlego to WikiPathwaysgo to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to article
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FluoropyrimidineActivity_WP1601go to articlego to articlego to articlego to pathway articlego to pathway articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to PubChem Compoundgo to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to pathway articlego to pathway articlego to articlego to articlego to articlego to articlego to articlego to WikiPathwaysgo to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to article
|{{{bSize}}}px|alt=Fluorouracil (5-FU) Activity edit]]
Fluorouracil (5-FU) Activity edit
  1. ^ The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601".
Click on genes, proteins and metabolites below to link to respective articles. [§ 1]
[[File:
IrinotecanPathway_WP46359go to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to article
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IrinotecanPathway_WP46359go to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to article
|{{{bSize}}}px|alt=Irinotecan Pathway edit]]
Irinotecan Pathway edit
  1. ^ The interactive pathway map can be edited at WikiPathways: "IrinotecanPathway_WP46359".

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000172831 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000091813 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Pindel EV, Kedishvili NY, Abraham TL, Brzezinski MR, Zhang J, Dean RA, Bosron WF (Jun 1997). "Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine and heroin". J Biol Chem. 272 (23): 14769–75. doi:10.1074/jbc.272.23.14769. PMID 9169443.
  6. ^ Schwer H, Langmann T, Daig R, Becker A, Aslanidis C, Schmitz G (Jun 1997). "Molecular cloning and characterization of a novel putative carboxylesterase, present in human intestine and liver". Biochem Biophys Res Commun. 233 (1): 117–20. doi:10.1006/bbrc.1997.6413. PMID 9144407.
  7. ^ a b "Entrez Gene: CES2 carboxylesterase 2 (intestine, liver)".
  8. ^ Imai T (Jun 2006). "Human Carboxylesterase Isozymes: Catalytic Properties and Rational Drug Design". Drug Metabolism and Pharmacokinetics. 21 (3): 173–185. doi:10.2133/dmpk.21.173. PMID 16858120.

Further reading[edit]