Carboxypeptidase A2

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Carboxypeptidase A2 (pancreatic)
Protein CPA2 PDB 1aye.png
PDB rendering based on 1aye.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbol CPA2
External IDs OMIM600688 MGI3617840 HomoloGene37541 ChEMBL: 4939 GeneCards: CPA2 Gene
EC number
RNA expression pattern
PBB GE CPA2 206212 at tn.png
More reference expression data
Species Human Mouse
Entrez 1358 232680
Ensembl ENSG00000158516 ENSMUSG00000071553
UniProt P48052 Q504N0
RefSeq (mRNA) NM_001869 NM_001024698
RefSeq (protein) NP_001860 NP_001019869
Location (UCSC) Chr 7:
130.27 – 130.29 Mb
Chr 6:
30.54 – 30.56 Mb
PubMed search [1] [2]

Carboxypeptidase A2 is an enzyme that in humans is encoded by the CPA2 gene.[1][2][3]

Three different forms of human pancreatic procarboxypeptidase A have been isolated. The A1 and A2 forms are monomeric proteins with different biochemical properties. The A2 form of pancreatic procarboxypeptidase acts on aromatic C-terminal residues[3]


  1. ^ Catasus L, Vendrell J, Aviles FX, Carreira S, Puigserver A, Billeter M (Apr 1995). "The sequence and conformation of human pancreatic procarboxypeptidase A2. cDNA cloning, sequence analysis, and three-dimensional model". J Biol Chem 270 (12): 6651–7. doi:10.1074/jbc.270.12.6651. PMID 7896805. 
  2. ^ Hayashida S, Yamasaki K, Asada Y, Soeda E, Niikawa N, Kishino T (Aug 2000). "Construction of a physical and transcript map flanking the imprinted MEST/PEG1 region at 7q32". Genomics 66 (2): 221–5. doi:10.1006/geno.2000.6206. PMID 10860668. 
  3. ^ a b "Entrez Gene: CPA2 carboxypeptidase A2 (pancreatic)". 

Further reading[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: M14.002