DePasqua was the head football coach for the WaynesburgYellow Jackets located in Waynesburg, Pennsylvania. He held that position for the 1966 and 1967 seasons. His coaching record at Waynesburg was 19 wins and 1 losses. As of the conclusion of the 2010 season, this ranks him #10 at Waynesburg in total wins and #2 at the school in winning percentage (.950).
DePasqua was an assistant coach for the University of Pittsburgh Panthers in the 1960s until the firing of head coach John Michelson after the 1965 season. In 1968, DePasqua served as an assistant coach in the NFL for the Pittsburgh Steelers before taking the position as the head coach with the University of PittsburghPanthers from 1969 to 1972. His Panther teams did turn in convincing wins against powerhouse teams such as West Virginia and Syracuse and posted a competitive season in 1970. His record at Pittsburgh was 13 wins and 29 losses, with a winning percentage of .310.