Carl Gräbe (24 February 1841 – 19 January 1927) was a German industrial and academic chemist from Frankfurt am Main who held professorships in his field at Leipzig, Königsberg, and Geneva. He is known for the first synthesis of the economically important dye, alizarin, with Liebermann, and for contributing to the fundamental nomenclature of organic chemistry.
Gräbe was born in Frankfurt in 1841. He studied at a vocational high school in Frankfurt and Karlsruhe Polytechnic and in Heidelberg. Later he worked for the chemical company Meister Lucius und Brüning (today Hoechst AG). He supervised the production of Fuchsine and researched violet colorants made using iodine. The work with iodine resulted in eye problems, so he returned to academia.
Carl Gräbe received his Ph.D. from the University of Heidelberg in 1862 under the supervision of Robert Wilhelm Bunsen. In 1868 he wrote his habilitation, and became a professor in Leipzig. Gräbe was Professor of Chemistry at the University of Königsberg from 1870 until 1877, and at the University of Geneva from 1878 until 1906. This was a period rich in the development of structural theory and nomenclature, and Gräbe is known for introducing the "ortho", "meta" and "para" nomenclature for naphthalene ring substitution.
Amongst Gräbe's students was Vera Bogdanovskaia, an early victim of the inherent risks of chemical research (dying as a result of later independent research on methylidynephosphane); her doctoral dissertation under Gräbe was on dibenzyl ketone (1892).
Gräbe synthesized the dye alizarin in 1868 with Carl Theodore Liebermann. Alizarin had been isolated from madder root some forty years earlier in 1826 by the French chemist Pierre Robiquet. Its chemical synthesis was a milestone in the development of the German and international dye industry, and foreshadowed collapse of the French agricultural sector that produced madder root (after synthesis became the more economical means of producing alizarin).
Gräbe died in Frankfurt in 1927.
- In 1869, Gräbe first used the prefixes ortho-, meta-, para- to denote specific relative locations of the substituents on a di-substituted aromatic ring (viz, naphthalene): Graebe (1869) "Ueber die Constitution des Naphthalins" (On the structure of naphthalene), Annalen der Chemie und Pharmacie, 149 : 20–28 ; see especially p. 26. In 1870, the German chemist Viktor Meyer first applied Gräbe's nomenclature to benzene: Victor Meyer (1870) "Untersuchungen über die Constitution der zweifach-substituirten Benzole" (Investigations into the structure of di-substituted benzenes), Annalen der Chemie und Pharmacie, 156 : 265–301 ; see especially pp. 299–300. See also: Hermann von Fehling, ed., Neues Handwörterbuch der Chemie [New concise dictionary of chemistry] (Braunschweig, Germany: Friedrich Vieweg und Sohn, 1874), vol. 1, p. 1142.
- Ogilvie, Marilyn. Biographical Dictionary of Women in Science. p. 311. ISBN 1135963436.
- Rayner-Canham, Marelene; Rayner-Canham, Geoffrey (2001). Women in Chemistry: Their Changing Roles from Alchemical Times to the Mid-twentieth Century. Philadelphia: Chemical Heritage Foundation. p. 64. ISBN 978-0-941901-27-7.