Carnosine synthase

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
carnosine synthase
EC no.
CAS no.9023-61-4
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Carnosine synthase (EC is an enzyme that catalyzes the chemical reaction

ATP + L-histidine + beta-alanine ADP + phosphate + carnosine

The 3 substrates of this enzyme are ATP, L-histidine, and beta-alanine, whereas its 3 products are ADP (previously thought to form AMP[1]), diphosphate, and carnosine.

This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases). The systematic name of this enzyme class is 'L-histidine:beta-alanine ligase (AMP-forming)' (incorrect on AMP-forming[2]). Other names in common use include 'carnosine synthetase', 'carnosine-anserine synthetase', 'homocarnosine synthetase', and 'carnosine-homocarnosine synthetase'.


The gene encoding this enzyme has been identified by Jakub Drozak and coworkers in 2010.[3] The gene encoding the Carnosine synthase is ATPGD1, a member of the “ATP-grasp family” of ligases. Because of its involvement in the formation of carnosine, this gene is now also named 'CARNS1'.[4]


  1. ^ "ENZYME - Carnosine synthase".
  2. ^ "Chemistry - Queen Mary University of London".
  3. ^ Drozak J, Veiga-da-Cunha M, Vertommen D, Stroobant V, Van Schaftingen E (Mar 2010). "Molecular identification of carnosine synthase as ATP-grasp domain-containing protein 1 (ATPGD1)". Journal of Biological Chemistry. 285 (13): 9346–56. doi:10.1074/jbc.M109.095505. PMC 2843183. PMID 20097752.
  4. ^ "Carnosine Synthase 1".