Carolyn R. Bertozzi
|Carolyn R. Bertozzi|
October 10, 1966 |
University of California, Berkeley
Lawrence Berkeley National Laboratory
University of California, San Francisco
|Alma mater||Harvard University
University of California, Berkeley
University of California, San Francisco
|Known for||bioorthogonal chemistry|
|Notable awards||MacArthur Foundation Fellowship (1999)
ACS Award in Pure Chemistry (2001)
Lemelson-MIT Prize (2010)
Heinrich Wieland Prize (2012)
|“Carolyn Bertozzi: Chemical Glycobiology”, iBiology|
Carolyn Ruth Bertozzi (born October 10, 1966) is an American chemist. At Stanford University, she holds the Anne T. and Robert M. Bass Professorship in the School of Humanities and Sciences;. In addition, Bertozzi is an Investigator at the Howard Hughes Medical Institute (HHMI) and is the former Director of the Molecular Foundry, a nanoscience research center at Lawrence Berkeley National Laboratory. She received a MacArthur "genius" award at age 33, making her one of the younger scientists to receive this award. In 2010 she was the first woman to receive the prestigious Lemelson-MIT Prize faculty award. She is a member of the National Academy of Sciences, the National Academy of Inventors, and the Institute of Medicine. In 2014, it was announced that Bertozzi would lead ACS Central Science, the American Chemical Society's first peer-reviewed open access journal that offers all content freely to the public.
Life and career
Born in Boston, Massachusetts, Bertozzi received her A.B. summa cum laude in chemistry from Harvard University, where she worked with Professor Joe Grabowski on the design and construction of a photoacoustic calorimeter. While an undergraduate, she played in various bands, including one with future Rage Against the Machine guitarist Tom Morello. After graduating she worked briefly at Bell Labs with Chris Chidsey and at Massachusetts General Hospital. Bertozzi is the daughter of physicist William Bertozzi and the younger sister of UCLA mathematician Andrea Bertozzi.
Bertozzi completed her Ph.D. in Chemistry at UC Berkeley in 1993 with Professor Mark Bednarski, working on the chemical synthesis of oligosaccharide analogs. She then was a postdoctoral fellow at UCSF with Professor Steven Rosen, where she studied the activity of endothelial oligosaccharides in promoting cell adhesion at inflammation sites. She was able to modify the protein and sugar molecules in the walls of living cells so that the cells do not reject foreign materials such as medical implants. Bertozzi joined the UC Berkeley faculty in 1996. She has been an investigator with HHMI since 2000.
Bertozzi studies the glycobiology underlying diseases such as cancer, inflammatory disorders such as arthritis, and infectious diseases such as tuberculosis. In particular, Bertozzi has advanced understanding of cell surface oligosaccharides involved in cell recognition and inter-cellular communication. Bertozzi is credited for developing the field of bioorthogonal chemistry which employs a bioorthogonal chemical reporters, such as the azide to label biomolecules within living systems. Her lab has also developed tools for research, including chemical tools for studying glycans in living systems and more recently nanotechnologies for probing biological systems.
In addition to her academic work, Bertozzi works actively with biotechnology start-ups. She has served on the research advisory board of GlaxoSmithKline, and has a startup of her own, Redwood Bioscience of Emeryville, California. Several of the technologies developed in her lab have been adapted for commercial use.
Significant papers and publications
- Mahal, Lara K.; Yarema, Kevin J.; Bertozzi, Carolyn R. (1997). "Engineering Chemical Reactivity on Cell Surfaces Through Oligosaccharide Biosynthesis". Science 276 (5315): 1125–8. doi:10.1126/science.276.5315.1125. PMID 9173543.
- Bertozzi, Carolyn R.; Kiessling, Laura L. (2001). "Chemical Glycobiology". Science 291 (5512): 2357–64. Bibcode:2001Sci...291.2357B. doi:10.1126/science.1059820. PMID 11269316.
- Saxon, Eliana; Bertozzi, Carolyn R. (2000). "Cell Surface Engineering by a Modified Staudinger Reaction". Science 287 (5460): 2007–10. Bibcode:2000Sci...287.2007S. doi:10.1126/science.287.5460.2007. PMID 10720325.
- Prescher, Jennifer A.; Bertozzi, Carolyn R. (2005). "Chemistry in living systems". Nature Chemical Biology 1 (1): 13–21. doi:10.1038/nchembio0605-13. PMID 16407987.
- Wang, Peng George; Bertozzi, Carolyn R., eds. (2001). Glycochemistry: Principles, Synthesis, and Applications. New York: Marcel Dekker. ISBN 978-0-8247-0538-1.
Awards and honors
- Phi Beta Kappa (1987)
- Beckman Young Investigators Award (1998)
- Arthur C. Cope Scholar Award of the American Chemical Society (1999)
- MacArthur Fellowship (1999)
- Berkeley's Distinguished Teaching Award (2001)
- ACS Award in Pure Chemistry (2001)
- Donald Sterling Noyce Prize for Excellence in Undergraduate Teaching (2001)
- Fellow of the American Association for the Advancement of Science (2002)
- Irving Sigal Young Investigator Award of the Protein Society (2002)
- Fellow of the American Academy of Arts and Sciences (2003)
- Agnes Fay Morgan Research Award of Iota Sigma Pi (2004)
- Havinga Medal, Univ. Leiden (2005)
- Member of the National Academy of Sciences (2005)
- Ernst Schering Prize (2007)
- Willard Gibbs Award (2008)
- Lemelson-MIT Prize (2010)
- Merck Academic Development Program Award
- Glaxo Wellcome Scholars' Award
- Presidential Early Career Award in Science and Engineering
- Camille Dreyfus Teacher-Scholar Award
- Horace S. Isbell Award in Carbohydrate Chemistry
- Alfred P. Sloan Research Fellowship
- Emanuel Merck Lectureship (2011)
- GLBT Scientist of the Year Award (2007) - from the National Organization of Gay and Lesbian Scientists and Technical Professionals
- Honorary Doctorate of Science from Brown University (2012)
- Heinrich Wieland Prize 2012 (2012)
- Adams, Amy. "Stanford chemist explains excitement of chemistry to students, the public". Stanford News. Retrieved 19 July 2015.
- "Carolyn Bertozzi honored by GLBT organization". UC Berkeley News. 27 February 2007. Retrieved 8 February 2013.
- "Carolyn Bertozzi". HHMI. Retrieved 8 February 2013.
- "Carolyn Bertozzi, Organic Chemist". MacArthur Foundation. Retrieved 3 February 2015.
- MacFarquhar, Neil (June 23, 1999). "32 Receive Grants From MacArthur Foundation". The New York Times. Retrieved 24 October 2015.
- Wang, Linda. "Carolyn Bertozzi To Lead ACS Central Science | Chemical & Engineering News". cen.acs.org. Retrieved 2015-08-19.
- Grabowski, Joseph J.; Bertozzi, Carolyn R.; Jacobsen, John R.; Jain, Ahamindra; Marzluff, Elaine M.; Suh, Annie Y. (1992). "Fluorescence probes in biochemistry: An examination of the non-fluorescent behavior of dansylamide by photoacoustic calorimetry". Analytical Biochemistry 207 (2): 214–26. doi:10.1016/0003-2697(92)90003-P. PMID 1481973.
- "Meet Carolyn Bertozzi". NIGMS. Retrieved 8 February 2013.
- "MIT Physics Department Faculty". Retrieved 4 June 2012.
- "UCLA Math Department Faculty". Retrieved 4 June 2012.
- "Bertozzi: Infectious In Her Enthusiasm". Chemical & Engineering News 78 (5): 26–35. January 31, 2000.
- Davis, T. (16 February 2010). "Profile of Carolyn Bertozzi". Proceedings of the National Academy of Sciences 107 (7): 2737–2739. doi:10.1073/pnas.0914469107. PMC 2840349. PMID 20160128. Retrieved 24 October 2015.
- Gardiner, Mary Beth (2005). "The Right Chemistry" (PDF). HHMI Bulletin. Winter 2005: 8–12. Retrieved 24 October 2015.
- "Carolyn Bertozzi". Chemical Heritage Foundation.
- "Carolyn Bertozzi 2010 Lemelson-MIT Prize". MIT. Retrieved 13 May 2014.
- McCook, Alison (March 6, 2013). "Women in Biotechnology: Barred from the Boardroom". Scientific American. Retrieved 24 October 2015.
- "Book of Members, 1780–2010: Chapter B" (PDF). American Academy of Arts and Sciences. Retrieved June 24, 2011.
- Cassell, Heather (February 22, 2007). "Two Bay Area gay scientists honored". Bay Area Reporter. Retrieved 24 October 2015.
- "Simmons among nine honorary degree recipients". Brown University. 16 May 2012. Retrieved 28 May 2014.
- "Heinrich Wieland Prize 2012 goes to Carolyn R. Bertozzi". Boehringer Ingelheim Foundation. 18 October 2012. Retrieved 30 June 2014.
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