Daly has also served as a radio DJ; he was formerly a nighttime host on the Los Angeles radio station KROQ-FM; beginning in 2010, Daly began hosting a morning show "Mornings with Carson Daly" on its sister station KAMP-FM. Daly also hosts a weekly top 30 countdown show "The Daly Download with Carson Daly" which is produced by CBS Radio (parent of KAMP-FM) and syndicated though Westwood One. The program airs on Saturday and Sunday mornings in a three or four hour edition on CHR/AC radio stations. He also co-founded an independent record label named 456 Entertainment.
Carson Daly hosted MTV'S TRL from 1998-2002. TRL was born out of two shows, "Total Request" and "MTV Live" both hosted by Daly. Daly's role as host of the popular live program included introducing the top 10 videos of the day and interviewing celebrity guests.
Carson Daly plays a small but pivotal role in the first episode of My Name Is Earl. While in the hospital after being hit by a car, Earl learns about karma from watching an episode of Last Call with Carson Daly where Daly claims that his success is a direct result of doing good things for other people. Earl is thus inspired by Carson Daly to turn his own life around, and sets out to make up for his many past wrongs. Carson Daly also had a small role on Dave Chappelle's show Chappelle's Show.
Daly's mother is a breast cancer survivor who was honored at Lifetime's 2004 Breast Cancer Heroes Luncheon. Daly has joined his mother in becoming a breast cancer activist.
Daly has three children with fiancée Siri Pinter (the daughter of actor Mark Pinter): a son, Jackson James Daly, born March 2009, and daughters, Etta Jones Daly, born in September 2012 and  London Rose Daly, born on August 20, 2014.