Cartilage oligomeric matrix protein

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This article is about the protein produced in humans. For other uses, see Comp.
Cartilage oligomeric matrix protein
Protein COMP PDB 1fbm.png
PDB rendering based on 1fbm.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM600310 MGI88469 HomoloGene74 GeneCards: COMP Gene
RNA expression pattern
PBB GE COMP 205713 s at tn.png
More reference expression data
Species Human Mouse
Entrez 1311 12845
Ensembl ENSG00000105664 ENSMUSG00000031849
UniProt P49747 Q9R0G6
RefSeq (mRNA) NM_000095 NM_016685
RefSeq (protein) NP_000086 NP_057894
Location (UCSC) Chr 19:
18.78 – 18.79 Mb
Chr 8:
70.37 – 70.38 Mb
PubMed search [1] [2]

Cartilage oligomeric matrix protein is a protein that in humans is encoded by the COMP gene.[1][2][3]

The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein.[4] It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfide bonds. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Mutations can cause the osteochondrodysplasias pseudoachondroplasia (PSACH) and multiple epiphyseal dysplasia (MED).[3]

COMP is a marker of cartilage turnover.[5]


  1. ^ Newton G, Weremowicz S, Morton CC, Copeland NG, Gilbert DJ, Jenkins NA, Lawler J (May 1995). "Characterization of human and mouse cartilage oligomeric matrix protein". Genomics 24 (3): 435–9. doi:10.1006/geno.1994.1649. PMID 7713493. 
  2. ^ Briggs MD, Rasmussen IM, Weber JL, Yuen J, Reinker K, Garber AP, Rimoin DL, Cohn DH (Mar 1994). "Genetic linkage of mild pseudoachondroplasia (PSACH) to markers in the pericentromeric region of chromosome 19". Genomics 18 (3): 656–60. doi:10.1016/S0888-7543(05)80369-6. PMID 8307576. 
  3. ^ a b "Entrez Gene: COMP cartilage oligomeric matrix protein". 
  4. ^ Paulsson M, Heinegård D (1981). "Purification and structural characterization of a cartilage matrix protein". Biochem. J. 197 (2): 367–75. PMC 1163135. PMID 7325960. 
  5. ^ Petersen, G.; Saxne, T.; Heinegard, D.; Hansen, M.; Holm, L.; Koskinen, S.; Stordal, C.; Christensen, H.; Aagaard, P.; Kjaer, M. (Jul 2009). "Glucosamine but not ibuprofen alters cartilage turnover in osteoarthritis patients in response to physical training1". Osteoarthritis and Cartilage 18 (1): 34–40. doi:10.1016/j.joca.2009.07.004. ISSN 1063-4584. PMID 19679221. 

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