Cartilage oligomeric matrix protein

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COMP
Protein COMP PDB 1fbm.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases COMP, EDM1, EPD1, MED, PSACH, THBS5, cartilage oligomeric matrix protein
External IDs OMIM: 600310 MGI: 88469 HomoloGene: 74 GeneCards: 1311
RNA expression pattern
PBB GE COMP 205713 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000095

NM_016685

RefSeq (protein)

NP_000086.2

NP_057894.2

Location (UCSC) Chr 19: 18.78 – 18.79 Mb Chr 8: 70.37 – 70.38 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Cartilage oligomeric matrix protein (COMP), also known as thrombospondin-5, is an extracellular matrix (ECM) protein primarily present in cartilage. In humans it is encoded by the COMP gene.[1][2][3]

Function[edit]

The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein.[4] It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfide bonds. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Mutations can cause the osteochondrodysplasias pseudoachondroplasia (PSACH) and multiple epiphyseal dysplasia (MED).[3]

COMP is a marker of cartilage turnover.[5] It is present in high quantities in fibrotic scars and systemic sclerosis, and it appears to have a role in vascular wall remodeling.[6]

References[edit]

  1. ^ Newton G, Weremowicz S, Morton CC, Copeland NG, Gilbert DJ, Jenkins NA, Lawler J (Dec 1994). "Characterization of human and mouse cartilage oligomeric matrix protein". Genomics 24 (3): 435–9. doi:10.1006/geno.1994.1649. PMID 7713493. 
  2. ^ Briggs MD, Rasmussen IM, Weber JL, Yuen J, Reinker K, Garber AP, Rimoin DL, Cohn DH (Dec 1993). "Genetic linkage of mild pseudoachondroplasia (PSACH) to markers in the pericentromeric region of chromosome 19". Genomics 18 (3): 656–60. doi:10.1016/S0888-7543(05)80369-6. PMID 8307576. 
  3. ^ a b "Entrez Gene: COMP cartilage oligomeric matrix protein". 
  4. ^ Paulsson M, Heinegård D (Aug 1981). "Purification and structural characterization of a cartilage matrix protein". The Biochemical Journal 197 (2): 367–75. PMC 1163135. PMID 7325960. 
  5. ^ Petersen SG, Saxne T, Heinegard D, Hansen M, Holm L, Koskinen S, Stordal C, Christensen H, Aagaard P, Kjaer M (Jan 2010). "Glucosamine but not ibuprofen alters cartilage turnover in osteoarthritis patients in response to physical training". Osteoarthritis and Cartilage / OARS, Osteoarthritis Research Society 18 (1): 34–40. doi:10.1016/j.joca.2009.07.004. PMID 19679221. 
  6. ^ Halper J, Kjaer M (2014). "Basic components of connective tissues and extracellular matrix: elastin, fibrillin, fibulins, fibrinogen, fibronectin, laminin, tenascins and thrombospondins". Advances in Experimental Medicine and Biology 802: 31–47. doi:10.1007/978-94-007-7893-1_3. PMID 24443019. 

Further reading[edit]

External links[edit]