Casein kinase 2

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The Casein kinase 2 (EC is a serine/threonine-selective protein kinase that is a tetramer of two alpha subunits and two beta subunits. The alpha subunits have the catalytic kinase domain. Casein kinase 2 has been implicated in cell cycle control, DNA repair, regulation of the circadian rhythm and other cellular processes.

Casein kinase 2 activity has been reported to be activated following Wnt signaling pathway activation.[1] A Pertussis toxin-sensitive G protein and Dishevelled appear to be an intermediary between Wnt-mediated activation of the Frizzled receptor and activation of casein kinase 2.

Mice that lack casein kinase 2 alpha prime have a defect in the morphology of developing sperm.[2]

casein kinase 2,
alpha 1 polypeptide
Symbol CSNK2A1
Entrez 1457
HUGO 2457
OMIM 115440
RefSeq NM_001895
UniProt P68400
Other data
EC number
Locus Chr. 20 p13
casein kinase 2,
alpha prime polypeptide
Symbol CSNK2A2
Entrez 1459
HUGO 2459
OMIM 115442
RefSeq NM_001896
UniProt P19784
Other data
EC number
Locus Chr. 16 [1]
casein kinase 2,
beta polypeptide
Symbol CSNK2B
Entrez 1460
HUGO 2460
OMIM 115441
RefSeq NM_001320
UniProt P67870
Other data
EC number
Locus Chr. 6 p21.3

See also[edit]


  1. ^ Gao Y, Wang HY (July 2006). "Casein kinase 2 Is activated and essential for Wnt/beta-catenin signaling". J. Biol. Chem. 281 (27): 18394–400. doi:10.1074/jbc.M601112200. PMID 16672224. 
  2. ^ Xu X, Toselli PA, Russell LD, Seldin DC (September 1999). "Globozoospermia in mice lacking the casein kinase II alpha' catalytic subunit". Nat. Genet. 23 (1): 118–21. doi:10.1038/12729. PMID 10471512.