Caspase 14

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Aliases CASP14
External IDs MGI: 1335092 HomoloGene: 36304 GeneCards: CASP14
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 19: 15.05 – 15.06 Mb Chr 10: 78.71 – 78.72 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Caspase 14 is an enzyme that in humans is encoded by the CASP14 gene.[3][4][5]

The CASP14 gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This caspase has been shown to be processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier.[5]

See also[edit]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Van de Craen M, Van Loo G, Pype S, Van Criekinge W, Van den brande I, Molemans F, Fiers W, Declercq W, Vandenabeele P (May 1999). "Identification of a new caspase homologue: caspase-14". Cell Death Differ. 5 (10): 838–46. doi:10.1038/sj.cdd.4400444. PMID 10203698. 
  4. ^ Hu S, Snipas SJ, Vincenz C, Salvesen G, Dixit VM (Dec 1998). "Caspase-14 is a novel developmentally regulated protease". J Biol Chem. 273 (45): 29648–53. doi:10.1074/jbc.273.45.29648. PMID 9792675. 
  5. ^ a b "Entrez Gene: CASP14 caspase 14, apoptosis-related cysteine peptidase". 

Further reading[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: C14.018