Caspase 4

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caspase 4, apoptosis-related cysteine peptidase
Symbol CASP4
Alt. symbols ICE(rel)II, ICH-2, TX
Entrez 837
HUGO 1505
OMIM 602664
RefSeq NM_001225
UniProt P49662
Other data
EC number
Locus Chr. 11 q22.2-q22.3

Caspase 4 is an enzyme that proteolytically cleaves other proteins at an aspartic acid residue (LEVD-), and belongs to a family of cysteine proteases called caspases. The function of caspase 4 is not fully known, but it is believed to be an inflammatory caspase, along with caspase 1, caspase 5 (and the murine homolog caspase 11), with a role in the immune system.[1]

See also[edit]


  1. ^ Martinon F, Tschopp J (2007). "Inflammatory caspases and inflammasomes: master switches of inflammation". Cell Death Differ. 14 (1): 10–22. doi:10.1038/sj.cdd.4402038. PMID 16977329. 

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: C14.007