Caspase recruitment domain-containing protein 8

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Available structures
PDB Human UniProt search: PDBe RCSB
Aliases CARD8, CARDINAL, DACAR, DAKAR, NDPP, NDPP1, TUCAN, caspase recruitment domain family member 8
External IDs HomoloGene: 136365 GeneCards: CARD8
Gene location (Human)
Chromosome 19 (human)
Chr. Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for CARD8
Genomic location for CARD8
Band 19q13.33 Start 48,180,770 bp[1]
End 48,255,946 bp[1]
RNA expression pattern
PBB GE CARD8 204950 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)


RefSeq (protein)


Location (UCSC) Chr 19: 48.18 – 48.26 Mb n/a
PubMed search [2] n/a
View/Edit Human

Caspase recruitment domain-containing protein 8 is an protein that in humans is encoded by the CARD8 gene.[3][4][5]


Caspase recruitment domain (CARD)-containing proteins, such as CARD8, are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NF-κB) in the context of apoptosis or inflammation, respectively.[5]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000105483 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". 
  3. ^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Jul 1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. PMID 10231032. doi:10.1093/dnares/6.1.63. 
  4. ^ Pathan N, Marusawa H, Krajewska M, Matsuzawa S, Kim H, Okada K, Torii S, Kitada S, Krajewski S, Welsh K, Pio F, Godzik A, Reed JC (Aug 2001). "TUCAN, an antiapoptotic caspase-associated recruitment domain family protein overexpressed in cancer". J Biol Chem. 276 (34): 32220–9. PMID 11408476. doi:10.1074/jbc.M100433200. 
  5. ^ a b "Entrez Gene: CARD8 caspase recruitment domain family, member 8". 

Further reading[edit]