Cation channels of sperm

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cation channel, sperm associated 1
Identifiers
Symbol CATSPER1
IUPHAR 388
Entrez 117144
HUGO 17116
OMIM 606389
RefSeq NM_053054
UniProt Q8NEC5
Other data
Locus Chr. 11 q12.1
cation channel, sperm associated 2
Identifiers
Symbol CATSPER2
IUPHAR 389
Entrez 117155
HUGO 18810
OMIM 607249
RefSeq NM_172097
UniProt Q96P55
Other data
Locus Chr. 15 q13-q15
cation channel, sperm associated 3
Identifiers
Symbol CATSPER3
IUPHAR 390
Entrez 347732
HUGO 20819
OMIM 609120
RefSeq NM_178019
UniProt Q86XQ3
Other data
Locus Chr. 5 q31.2
cation channel, sperm associated 4
Identifiers
Symbol CATSPER4
IUPHAR 391
Entrez 378807
HUGO 23220
OMIM 609121
RefSeq NM_198137
UniProt Q7RTX7
Other data
Locus Chr. 1 p35.3

The cation channels of sperm also known as Catsper channels or CatSper, are ion channels that are related to the two-pore channels and distantly related to TRP channels. The four members of this family form voltage-gated Ca2+ channels that seem to be specific to sperm. As sperm encounter the more alkaline environment of the female reproductive tract, CatSper channels become activated by the altered ion concentration. These channels are required for proper fertilization.[1] The study of these channels has been slow because they do not traffic to the cell membrane in many heterologous systems.

Of the four members of the Catsper family, Catsper1 is found in the primary piece of sperm. Catsper1 plays an important role in evoked Ca2+ entry and regulation of hyperactivation in sperm. Catsper2 is localized in the sperm tail and is responsible for regulation of hyperactivation. Catsper3 and Catsper4 are found in both, the testes and sperm and play an important role in the motility of hyperactivated sperm. Although Catsper seems to play an important role in sperm function, Catspers1-4 null mice have been found to have normal testicular histology, sperm counts and morphology, which is indicative of normal progression of spermatogenesis. [2]

See also[edit]

References[edit]

  1. ^ Qi H, Moran MM, Navarro B, Chong JA, Krapivinsky G, Krapivinsky L, Kirichok Y, Ramsey IS, Quill TA, Clapham DE (January 2007). "All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility". Proc. Natl. Acad. Sci. U.S.A. 104 (4): 1219–23. doi:10.1073/pnas.0610286104. PMC 1770895Freely accessible. PMID 17227845. 
  2. ^ Eun Hwa Park, Do Rim Kim, Ha Young Kim, Seong Kyu Park, and Mun Seog Chang. Panax ginseng induces the expression of CatSper genes and sperm hyper activation. Asian journal of andrology 2014;16(6):845-851.

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