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Cation channel, sperm associated 1
External IDs OMIM606389 MGI2179947 HomoloGene14207 IUPHAR: 388 ChEMBL: 1628462 GeneCards: CATSPER1 Gene
Species Human Mouse
Entrez 117144 225865
Ensembl ENSG00000175294 ENSMUSG00000038498
UniProt Q8NEC5 Q91ZR5
RefSeq (mRNA) NM_053054 NM_139301
RefSeq (protein) NP_444282 NP_647462
Location (UCSC) Chr 11:
66.02 – 66.03 Mb
Chr 19:
5.34 – 5.34 Mb
PubMed search [1] [2]

CatSper1, is a protein which in humans is encoded by the CATSPER1 gene.[1][2][3] CatSper1 is a member of the cation channels of sperm family of protein. The four proteins in this family together form a Ca2+-permeant ion channel specific essential for the correct function of sperm cells.[4]


Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region.[5]


  1. ^ Quill TA, Ren D, Clapham DE, Garbers DL (October 2001). "A voltage-gated ion channel expressed specifically in spermatozoa". Proc. Natl. Acad. Sci. U.S.A. 98 (22): 12527–31. doi:10.1073/pnas.221454998. PMC 60087. PMID 11675491. 
  2. ^ Ren D, Navarro B, Perez G, Jackson AC, Hsu S, Shi Q, Tilly JL, Clapham DE (October 2001). "A sperm ion channel required for sperm motility and male fertility". Nature 413 (6856): 603–9. doi:10.1038/35098027. PMID 11595941. 
  3. ^ Clapham DE, Garbers DL (December 2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels". Pharmacol. Rev. 57 (4): 451–4. doi:10.1124/pr.57.4.7. PMID 16382101. 
  4. ^ "CatSper and Two-Pore Channels: Introduction". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 
  5. ^ "Entrez Gene: CatSper1". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.