Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region. This gene is part of a tandem repeat on chromosome 15q15; the second copy of this gene is thought to be a pseudogene.
^Clapham DE, Garbers DL (December 2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels". Pharmacol. Rev.57 (4): 451–4. doi:10.1124/pr.57.4.7. PMID16382101.
Zhang D, Chen J, Saraf A; et al. (2006). "Association of Catsper1 or -2 with Ca(v)3.3 leads to suppression of T-type calcium channel activity.". J. Biol. Chem.281 (31): 22332–41. doi:10.1074/jbc.M511288200. PMID16740636.
Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet.36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.
Clapham DE, Garbers DL (2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels.". Pharmacol. Rev.57 (4): 451–4. doi:10.1124/pr.57.4.7. PMID16382101.