CatSper2

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CATSPER2
Identifiers
Aliases CATSPER2, CatSper2
External IDs MGI: 2387404 HomoloGene: 77423 GeneCards: CATSPER2
Targeted by Drug
alprostadil, dinoprostone, progesterone, mibefradil[1]
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001282309
NM_001282310
NM_054020
NM_172095
NM_172097

NM_153075

RefSeq (protein)

NP_001269238
NP_001269239
NP_473361
NP_742093

n/a

Location (UCSC) Chr 15: 43.63 – 43.67 Mb Chr 2: 121.39 – 121.41 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

CatSper2, is a protein which in humans is encoded by the CATSPER2 gene.[4][5] CatSper2 is a member of the cation channels of sperm family of protein. The four proteins in this family together form a Ca2+-permeant ion channel specific essential for the correct function of sperm cells.[6]

Function[edit]

Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region. This gene is part of a tandem repeat on chromosome 15q15; the second copy of this gene is thought to be a pseudogene.[7]

References[edit]

  1. ^ "Drugs that physically interact with Cation channel sperm associated 2 view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ Quill TA, Ren D, Clapham DE, Garbers DL (October 2001). "A voltage-gated ion channel expressed specifically in spermatozoa". Proc. Natl. Acad. Sci. U.S.A. 98 (22): 12527–31. doi:10.1073/pnas.221454998. PMC 60087Freely accessible. PMID 11675491. 
  5. ^ Clapham DE, Garbers DL (December 2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels". Pharmacol. Rev. 57 (4): 451–4. doi:10.1124/pr.57.4.7. PMID 16382101. 
  6. ^ *"CatSper and Two-Pore Channels: Introduction". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 
  7. ^ "Entrez Gene: CatSper2". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.