CatSper4

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CATSPER4
Identifiers
Aliases CATSPER4, CatSper4
External IDs MGI: 3043288 HomoloGene: 18638 GeneCards: CATSPER4
Targeted by Drug
alprostadil, dinoprostone, progesterone, mibefradil[1]
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_198137

NM_001130030
NM_177866

RefSeq (protein)

NP_937770

NP_001123502.1
NP_808534.1

Location (UCSC) Chr 1: 26.19 – 26.2 Mb Chr 4: 134.21 – 134.23 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

CatSper4, is a protein which in humans is encoded by the CATSPER4 gene.[4][5][6] CatSper1 is a member of the cation channels of sperm family of protein. The four proteins in this family together form a Ca2+-permeant ion channel specific essential for the correct function of sperm cells.[7]

References[edit]

  1. ^ "Drugs that physically interact with Cation channel sperm associated 4 view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ Lobley A, Pierron V, Reynolds L, Allen L, Michalovich D (August 2003). "Identification of human and mouse CatSper3 and CatSper4 genes: characterisation of a common interaction domain and evidence for expression in testis". Reprod. Biol. Endocrinol. 1: 53. doi:10.1186/1477-7827-1-53. PMC 184451Freely accessible. PMID 12932298. 
  5. ^ Qi H, Moran MM, Navarro B, Chong JA, Krapivinsky G, Krapivinsky L, Kirichok Y, Ramsey IS, Quill TA, Clapham DE (January 2007). "All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility". Proc. Natl. Acad. Sci. U.S.A. 104 (4): 1219–23. doi:10.1073/pnas.0610286104. PMC 1770895Freely accessible. PMID 17227845. 
  6. ^ Clapham DE, Garbers DL (December 2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels". Pharmacol. Rev. 57 (4): 451–4. doi:10.1124/pr.57.4.7. PMID 16382101. 
  7. ^ *"CatSper and Two-Pore Channels: Introduction". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.