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External IDs OMIM609121 MGI3043288 HomoloGene18638 IUPHAR: 391 GeneCards: CATSPER4 Gene
Species Human Mouse
Entrez 378807 329954
Ensembl ENSG00000188782 ENSMUSG00000048003
UniProt Q7RTX7 Q8BVN3
RefSeq (mRNA) NM_198137 NM_177866
RefSeq (protein) NP_937770 NP_808534
Location (UCSC) Chr 1:
134.33 – 134.38 Mb
Chr 4:
133.77 – 133.78 Mb
PubMed search [1] [2]

CatSper4, is a protein which in humans is encoded by the CATSPER4 gene.[1][2][3] CatSper1 is a member of the cation channels of sperm family of protein. The four proteins in this family together form a Ca2+-permeant ion channel specific essential for the correct function of sperm cells.[4]


  1. ^ Lobley A, Pierron V, Reynolds L, Allen L, Michalovich D (August 2003). "Identification of human and mouse CatSper3 and CatSper4 genes: characterisation of a common interaction domain and evidence for expression in testis". Reprod. Biol. Endocrinol. 1: 53. doi:10.1186/1477-7827-1-53. PMC 184451. PMID 12932298. 
  2. ^ Qi H, Moran MM, Navarro B, Chong JA, Krapivinsky G, Krapivinsky L, Kirichok Y, Ramsey IS, Quill TA, Clapham DE (January 2007). "All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility". Proc. Natl. Acad. Sci. U.S.A. 104 (4): 1219–23. doi:10.1073/pnas.0610286104. PMC 1770895. PMID 17227845. 
  3. ^ Clapham DE, Garbers DL (December 2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels". Pharmacol. Rev. 57 (4): 451–4. doi:10.1124/pr.57.4.7. PMID 16382101. 
  4. ^ *"CatSper and Two-Pore Channels: Introduction". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.