The cathedral was constructed in the 1850s, during the time of vicar Andrea Canova. The first organ in Bulgaria was installed in the cathedral in 1861, later substituted with a newer and larger one. A fire severely damaged the cathedral in 1931 and destroyed the wood-carved ceiling. The cathedral was reconstructed, with Krastyo Stamatov creating the frescoes and Kamen Petkov being the main architect. The cathedral was once again inaugurated on 8 May 1932. Architecturally, it features an eclectic combination of Neoclassicism and Neo-Baroque.