Cathepsin A

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CTSA
Protein CTSA PDB 1ivy.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCTSA, GLB2, GSL, NGBE, PPCA, PPGB, cathepsin A
External IDsOMIM: 613111 MGI: 97748 HomoloGene: 80163 GeneCards: CTSA
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for CTSA
Genomic location for CTSA
Band20q13.12Start45,890,144 bp[1]
End45,898,820 bp[1]
RNA expression pattern
PBB GE CTSA 200661 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001167594
NM_000308
NM_001127695

NM_001038492
NM_008906

RefSeq (protein)

NP_000299
NP_001121167
NP_001161066

NP_001033581
NP_032932

Location (UCSC)Chr 20: 45.89 – 45.9 MbChr 2: 164.83 – 164.84 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cathepsin A is an enzyme that is classified both as a cathepsin and a carboxypeptidase. In humans, it is encoded by the CTSA gene.[5]

Function[edit]

This gene encodes a glycoprotein that associates with lysosomal enzymes beta-galactosidase and neuraminidase to form a complex of high-molecular-weight multimers. The formation of this complex provides a protective role for stability and activity. It is protective for β-galactosidase and neuraminidase.[6]

Clinical significance[edit]

Deficiencies in this gene are linked to multiple forms of galactosialidosis.[5]

Interactions[edit]

Cathepsin A has been shown to interact with NEU1.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000064601 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000017760 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ a b "Entrez Gene: CTSA cathepsin A". 
  6. ^ Mitchell, Richard Sheppard; Kumar, Vinay; Robbins, Stanley L.; Abbas, Abul K.; Fausto, Nelson (2007). "Table 7-6". Robbins basic pathology (8th ed.). Saunders/Elsevier. ISBN 1-4160-2973-7. 
  7. ^ van der Spoel, A; Bonten E; d'Azzo A (Mar 1998). "Transport of human lysosomal neuraminidase to mature lysosomes requires protective protein/cathepsin A". EMBO J. ENGLAND. 17 (6): 1588–97. doi:10.1093/emboj/17.6.1588. ISSN 0261-4189. PMC 1170506Freely accessible. PMID 9501080. 

Further reading[edit]

External links[edit]