Cathepsin A

From Wikipedia, the free encyclopedia
Jump to: navigation, search
CTSA
Protein CTSA PDB 1ivy.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CTSA, GLB2, GSL, NGBE, PPCA, PPGB, cathepsin A
External IDs OMIM: 613111 MGI: 97748 HomoloGene: 80163 GeneCards: 5476
RNA expression pattern
PBB GE CTSA 200661 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001167594
NM_000308
NM_001127695

NM_001038492
NM_008906

RefSeq (protein)

NP_001121167.1
NP_000299.2
NP_001161066.1

NP_001033581.1

Location (UCSC) Chr 20: 45.89 – 45.9 Mb Chr 2: 164.83 – 164.84 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Cathepsin A is an enzyme that is classified both as a cathepsin and a carboxypeptidase. In humans, it is encoded by the CTSA gene.[1]

Function[edit]

This gene encodes a glycoprotein that associates with lysosomal enzymes beta-galactosidase and neuraminidase to form a complex of high-molecular-weight multimers. The formation of this complex provides a protective role for stability and activity. It is protective for β-galactosidase and neuraminidase.[2]

Clinical significance[edit]

Deficiencies in this gene are linked to multiple forms of galactosialidosis.[1]

Interactions[edit]

Cathepsin A has been shown to interact with NEU1.[3]

References[edit]

  1. ^ a b "Entrez Gene: CTSA cathepsin A". 
  2. ^ Mitchell, Richard Sheppard; Kumar, Vinay; Robbins, Stanley L.; Abbas, Abul K.; Fausto, Nelson (2007). "Table 7-6". Robbins basic pathology (8th ed.). Saunders/Elsevier. ISBN 1-4160-2973-7. 
  3. ^ van der Spoel, A; Bonten E; d'Azzo A (Mar 1998). "Transport of human lysosomal neuraminidase to mature lysosomes requires protective protein/cathepsin A". EMBO J. (ENGLAND) 17 (6): 1588–97. doi:10.1093/emboj/17.6.1588. ISSN 0261-4189. PMC 1170506. PMID 9501080. 

Further reading[edit]

External links[edit]