Cathepsin L2

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Protein CTSL2 PDB 1fh0.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases CTSV, cathepsin V, CATL2, CTSL2, CTSU
External IDs MGI: 88564 HomoloGene: 76699 GeneCards: CTSV
Gene location (Human)
Chromosome 9 (human)
Chr. Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for CTSV
Genomic location for CTSV
Band 9q22.33 Start 97,029,679 bp[1]
End 97,039,643 bp[1]
RNA expression pattern
PBB GE CTSL2 210074 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 9: 97.03 – 97.04 Mb Chr 13: 64.36 – 64.37 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Cathepsin L2, also known as cathepsin V and encoded by the CTSL2 gene, is a human gene.[5]

The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may play an important role in corneal physiology. This gene is expressed in colorectal and breast carcinomas but not in normal colon, mammary gland, or peritumoral tissues, suggesting a possible role for this gene in tumor processes.

Clinical significance[edit]

Cathepsin L2 may play a role in the pathogenesis of keratoconus.[6]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000136943 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021477 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ "Entrez Gene: CTSL2 cathepsin L2". 
  6. ^ Kenney MC, Chwa M, Atilano SR, Tran A, Carballo M, Saghizadeh M, Vasiliou V, Adachi W, Brown DJ (2005). "Increased levels of catalase and cathepsin V/L2 but decreased TIMP-1 in keratoconus corneas: evidence that oxidative stress plays a role in this disorder". Invest. Ophthal. Vis. Sci. 46: 823–832. doi:10.1167/iovs.04-0549. PMID 15728537. 

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: C01.009

Further reading[edit]