Cathepsin O

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Cathepsin O
Symbols CTSO ; CTSO1
External IDs OMIM600550 MGI2139628 HomoloGene1020 ChEMBL: 3035 GeneCards: CTSO Gene
EC number
Species Human Mouse
Entrez 1519 229445
Ensembl ENSG00000256043 ENSMUSG00000028015
UniProt P43234 Q8BM88
RefSeq (mRNA) NM_001334 NM_177662
RefSeq (protein) NP_001325 NP_808330
Location (UCSC) Chr 4:
155.92 – 155.95 Mb
Chr 3:
81.93 – 81.96 Mb
PubMed search [1] [2]

Cathepsin O is an enzyme that in humans is encoded by the CTSO gene.[1][2]


Cathepsin O is a cysteine protease and a member of the cathepsin family and papain superfamily. This proteolytic enzyme is involved in cellular protein degradation and turnover. The recombinant form of this enzyme was shown to degrade synthetic peptides typically used as substrates for cysteine proteinases and its proteolytic activity was abolished by an inhibitor of cyteine proteinase.[2]


  1. ^ Santamaría I, Pendás AM, Velasco G, López-Otín C (October 1998). "Genomic structure and chromosomal localization of the human cathepsin O gene (CTSO)". Genomics 53 (2): 231–4. doi:10.1006/geno.1997.5180. PMID 9790772. 
  2. ^ a b "Entrez Gene: cathepsin O". 

Further reading[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: C01.035

This article incorporates text from the United States National Library of Medicine, which is in the public domain.