Cathepsin W

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Aliases CTSW, LYPN, cathepsin W
External IDs MGI: 1338045 HomoloGene: 37471 GeneCards: CTSW
Gene location (Human)
Chromosome 11 (human)
Chr. Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for CTSW
Genomic location for CTSW
Band 11q13.1 Start 65,879,809 bp[1]
End 65,883,741 bp[1]
RNA expression pattern
PBB GE CTSW 214450 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 11: 65.88 – 65.88 Mb Chr 19: 5.47 – 5.47 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Cathepsin W is a protein that in humans is encoded by the CTSW gene.[5][6][7]

The protein encoded by this gene, a member of the peptidase C1 family, is a cysteine proteinase that may have a specific function in the mechanism or regulation of T-cell cytolytic activity. The encoded protein is found associated with the membrane inside the endoplasmic reticulum of natural killer and cytotoxic T-cells. Expression of this gene is up-regulated by interleukin-2.[7]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000172543 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024910 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Linnevers C, Smeekens SP, Bromme D (May 1997). "Human cathepsin W, a putative cysteine protease predominantly expressed in CD8+ T-lymphocytes". FEBS Lett. 405 (3): 253–9. doi:10.1016/S0014-5793(97)00118-X. PMID 9108299. 
  6. ^ Wex T, Levy B, Smeekens SP, Ansorge S, Desnick RJ, Bromme D (Aug 1998). "Genomic structure, chromosomal localization, and expression of human cathepsin W". Biochem Biophys Res Commun. 248 (2): 255–61. doi:10.1006/bbrc.1998.8954. PMID 9675123. 
  7. ^ a b "Entrez Gene: CTSW cathepsin W". 

Further reading[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: C01.037