Cathepsin W

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CTSW
Identifiers
Aliases CTSW, LYPN, cathepsin W
External IDs MGI: 1338045 HomoloGene: 37471 GeneCards: 1521
RNA expression pattern
PBB GE CTSW 214450 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001335

NM_009985

RefSeq (protein)

NP_001326.2

NP_034115.2

Location (UCSC) Chr 11: 65.88 – 65.88 Mb Chr 19: 5.47 – 5.47 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Cathepsin W is a protein that in humans is encoded by the CTSW gene.[1][2][3]

The protein encoded by this gene, a member of the peptidase C1 family, is a cysteine proteinase that may have a specific function in the mechanism or regulation of T-cell cytolytic activity. The encoded protein is found associated with the membrane inside the endoplasmic reticulum of natural killer and cytotoxic T-cells. Expression of this gene is up-regulated by interleukin-2.[3]

References[edit]

  1. ^ Linnevers C, Smeekens SP, Bromme D (May 1997). "Human cathepsin W, a putative cysteine protease predominantly expressed in CD8+ T-lymphocytes". FEBS Lett 405 (3): 253–9. doi:10.1016/S0014-5793(97)00118-X. PMID 9108299. 
  2. ^ Wex T, Levy B, Smeekens SP, Ansorge S, Desnick RJ, Bromme D (Aug 1998). "Genomic structure, chromosomal localization, and expression of human cathepsin W". Biochem Biophys Res Commun 248 (2): 255–61. doi:10.1006/bbrc.1998.8954. PMID 9675123. 
  3. ^ a b "Entrez Gene: CTSW cathepsin W". 

Further reading[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: C01.037