Cathepsin W

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Cathepsin W
Symbols CTSW ; LYPN
External IDs OMIM602364 MGI1338045 HomoloGene37471 GeneCards: CTSW Gene
RNA expression pattern
PBB GE CTSW 214450 at tn.png
More reference expression data
Species Human Mouse
Entrez 1521 13041
Ensembl ENSG00000172543 ENSMUSG00000024910
UniProt P56202 P56203
RefSeq (mRNA) NM_001335 NM_009985
RefSeq (protein) NP_001326 NP_034115
Location (UCSC) Chr 11:
65.88 – 65.88 Mb
Chr 19:
5.47 – 5.47 Mb
PubMed search [1] [2]

Cathepsin W is a protein that in humans is encoded by the CTSW gene.[1][2][3]

The protein encoded by this gene, a member of the peptidase C1 family, is a cysteine proteinase that may have a specific function in the mechanism or regulation of T-cell cytolytic activity. The encoded protein is found associated with the membrane inside the endoplasmic reticulum of natural killer and cytotoxic T-cells. Expression of this gene is up-regulated by interleukin-2.[3]


  1. ^ Linnevers C, Smeekens SP, Bromme D (May 1997). "Human cathepsin W, a putative cysteine protease predominantly expressed in CD8+ T-lymphocytes". FEBS Lett 405 (3): 253–9. doi:10.1016/S0014-5793(97)00118-X. PMID 9108299. 
  2. ^ Wex T, Levy B, Smeekens SP, Ansorge S, Desnick RJ, Bromme D (Aug 1998). "Genomic structure, chromosomal localization, and expression of human cathepsin W". Biochem Biophys Res Commun 248 (2): 255–61. doi:10.1006/bbrc.1998.8954. PMID 9675123. 
  3. ^ a b "Entrez Gene: CTSW cathepsin W". 

Further reading[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: C01.037