Cathepsin Z

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Cathepsin Z
Protein CTSZ PDB 1deu.png
PDB rendering based on 1deu.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CTSZ ; CTSX
External IDs OMIM603169 MGI1891190 HomoloGene1022 IUPHAR: 2354 ChEMBL: 4160 GeneCards: CTSZ Gene
EC number
RNA expression pattern
PBB GE CTSZ 210042 s at tn.png
More reference expression data
Species Human Mouse
Entrez 1522 64138
Ensembl ENSG00000101160 ENSMUSG00000016256
UniProt Q9UBR2 Q9WUU7
RefSeq (mRNA) NM_001336 NM_022325
RefSeq (protein) NP_001327 NP_071720
Location (UCSC) Chr 20:
59 – 59.01 Mb
Chr 2:
174.43 – 174.44 Mb
PubMed search [1] [2]

Cathepsin Z or cathepsin X is a protein that in humans is encoded by the CTSZ gene.[1][2]The encoded protein has also been known as cathepsin X and cathepsin P.


At least two transcript variants of this gene have been found, but the full-length nature of only one of them has been determined.The gene has 6 exons and locates at chromosome band 20q13.32.[2]


The protein encoded by this gene is a lysosomal cysteine proteinase and member of the peptidase C1 family. It exhibits both carboxy-monopeptidase and carboxy-dipeptidase activities. Up to date, nine human cysteine proteinases have been identified, including cathepsin B, cathepsin C, cathepsin H, cathepsin K, cathepsin L, cathepsin L2, cathepsin O, cathepsin S, and cathepsin W. These cysteine proteinases belong to the papain family and represent a major component of the lysosomal proteolytic system.In addition to playing a critical role in protein degradation and turnover, these proteinases appear to play an extracellular role in a number of normal and pathological conditions.

Clinical Significance[edit]

This gene is expressed ubiquitously in cancer cell lines and primary tumors and, like other members of this family, may be involved in tumorigenesis.


  1. ^ Santamaria I, Velasco G, Pendas AM, Fueyo A, Lopez-Otin C (Aug 1998). "Cathepsin Z, a novel human cysteine proteinase with a short propeptide domain and a unique chromosomal location". J Biol Chem 273 (27): 16816–23. doi:10.1074/jbc.273.27.16816. PMID 9642240. 
  2. ^ a b "Entrez Gene: CTSZ cathepsin Z". 

Further reading[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: C01.013