Caulimoviridae

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Caulimoviridae
Virus classification
Group: Group VII (dsDNA-RT)
Family: Caulimoviridae
Genera

Caulimoviridae is a family of viruses. Plants and insects serve as natural hosts. There are currently 53 species in this family, divided among 8 genera.[1][2] Viruses belonging to the Caulimoviridae family are termed DNA reverse-transcribing viruses (or pararetroviruses) i.e. viruses that contain a reverse transcription stage in their replication cycle. This family contains all plant viruses that consist of a double-stranded DNA genome that has a reverse transcribing phase in its lifecycle.

Taxonomy[edit]

Group: ssRNA-RT

[2]

The Rose yellow vein virus has an unusual genome organisation that appears to be unique in this family.[3]

Virus particle structure[edit]

All viruses of this family are non-enveloped. Virus particles contain nucleocapsids one of two forms; either bacilliform or isometric. The type of nucleocapsid incorporated into the virus structure determines the size of the virus. Bacilliform nucleocapsid viruses are approximately 35-50 nm diameter and can be 900 nm in length. Isometric nucleocapsid viruses are on average 45-50 nm in diameter and show icosahdral symmetry.

Genome structure and replication[edit]

The genomes of viruses from this family contain monopartite, double-stranded DNA in either an open circular or linear structure. The size of the genome is usually between 6000-8000 base pairs. Depending on the virus, DNA can contain either one open reading frame (ORF) as observed in Petuviruses, or up to eight ORFs such as in the Soymoviruses. Proteins found to be encoded in this virus family genome include reverse transcriptase, proteases, nucleocapsids and transactivators - there are other proteins essential for replication that have yet to be assigned a specific function.

Genus Structure Symmetry Capsid Genomic Arrangement Genomic Segmentation
Rosadnavirus Icosahedral T=7 Non-Enveloped Circular Monopartite
Cavemovirus Icosahedral T=7 Non-Enveloped Circular Monopartite
Petuvirus Icosahedral T=7 Non-Enveloped Circular Monopartite
Caulimovirus Icosahedral T=7 Non-Enveloped Circular Monopartite
Soymovirus Icosahedral T=7 Non-Enveloped Circular Monopartite
Badnavirus Bacilliform T=3 Non-Enveloped Circular Monopartite
Solendovirus Icosahedral T=7 Non-Enveloped Circular Monopartite
Tungrovirus Bacilliform T=3 Non-Enveloped Circular Monopartite

Replication takes place in both the cytoplasm and nucleus of host cells. Firstly, the viral genome enters the cytoplasm. The viral DNA forms supercoiled mini-chromosome structures upon entering the host nucleus. The viral DNA is transcribed into polyadenylated RNA which is terminally redundant (due to transcription occurring twice for some parts of the DNA). Newly transcribed RNA enters the cytoplasm once more where it has two roles. It can either be used as a template for viral protein synthesis, or it can undergo reverse transcription by viral encoded reverse transcriptase to make dsDNA. This DNA can then reenter the nucleus for amplification.

As replication requires the use of RNA intermediate, viruses from the Caulimoviridae family are not true dsDNA viruses - instead they are termed DNA reverse-transcribing viruses. As this property is also found in retroviruses, these families have been compared. However, there are several important differences between retroviruses and viruses from the Caulimoviridae family. Unlike retroviruses, they do not require the integration of viral genome into the host's in order to replicate and for this reason their genome does not encode the enzymatic protein integrase.

Although they do not regularly integrate into the host genome, sequences from certain caulimoviruses, such as Petunia vein clearing virus and Banana streak virus have been found in host genomes.[4] These are termed Endogenous Pararetroviruses, or EPRVs.

Genus Host Details Tissue Tropism Entry Details Release Details Replication Site Assembly Site Transmission
Rosadnavirus Plants None Viral movement; mechanical inoculation Viral movement Nucleus Cytoplasm Mechanical inoculation: aphids
Cavemovirus Plants None Viral movement; mechanical inoculation Viral movement Nucleus Cytoplasm Mechanical inoculation: aphids
Petuvirus Plants None Viral movement; mechanical inoculation Viral movement Nucleus Cytoplasm Grafting
Caulimovirus Plants None Viral movement; mechanical inoculation Viral movement Nucleus Cytoplasm Mechanical inoculation: aphids
Soymovirus Plants None Viral movement; mechanical inoculation Viral movement Nucleus Cytoplasm Mechanical inoculation: aphids
Badnavirus Plants None Viral movement; mechanical inoculation Viral movement Nucleus Cytoplasm Mechanical inoculation: mealybugs; mechanical; wounds; seed
Solendovirus Plants None Viral movement; mechanical inoculation Viral movement Nucleus Cytoplasm Seeds
Tungrovirus Plants None Viral movement; mechanical inoculation Viral movement Nucleus Cytoplasm Mechanical inoculation: aphids

References[edit]

  1. ^ "Viral Zone". ExPASy. Retrieved 15 June 2015. 
  2. ^ a b ICTV. "Virus Taxonomy: 2014 Release". Retrieved 15 June 2015. 
  3. ^ Mollov D, Lockhart B, Zlesak DC, Olszewski N (2012) Complete nucleotide sequence of rose yellow vein virus, a member of the family Caulimoviridae having a novel genome organization. Arch Virol
  4. ^ http://arjournals.annualreviews.org/doi/abs/10.1146/annurev.phyto.40.120301.105642

External links[edit]